DrugsPRO

Library 2,5-DMA 2,5-DMA is a research chemical and the simplest member of the DOx family, primarily known as a precursor in synthesizing other psychedelic amphetamines rather than for its own psychoactive effects. Unlike typical psychedelics, it produces primarily stimulant and physical effects with minimal to no sensory or perceptual changes. Very little data exists about its pharmacology, metabolism, and toxicity. Use accurate weighing equipment and start with lower doses due to individual variability. Those with personal or family history of mental health disorders should avoid use. Library 2-AI 2-AI is a rigid amphetamine analogue that surfaced as a research chemical in the early 2000s. Reports describe mild, functional stimulation with minimal euphoria. Toxicology data remain sparse and some jurisdictions regulate it alongside amphetamine analogues. In vitro studies show robust activity at NET (EC50 approximately 0.14 uM) and DAT (EC50 approximately 0.31 uM) with negligible SERT activity. Start with allergy tests and conservative doses as individual responses vary widely. Library 2-Aminoindane 2-Aminoindane is a synthetic stimulant of the aminoindane class and a rigid structural analogue of amphetamine in which the propane chain is cyclized back onto the benzene ring. It first appeared on the research chemical market around 2003 and has been sold as a designer drug. Its effects have been compared to those of benzylpiperazine and methamphetamine, though very little is known about its recreational use profile. Library 2-Bromoamphetamine Library 2-Bromomethamphetamine Library 2-FA 2-FA is a synthetic stimulant of the substituted amphetamine class, distinguished by a fluorine atom at the 2-position of the amphetamine structure. It first emerged on the online research chemical market in the 2010s as part of a series of fluorinated amphetamine analogs. Among these, 2-FA is regarded as the most closely resembling conventional amphetamine in its subjective effects and is frequently compared to dextroamphetamine. It is considered habit-forming. Library 2-FEA 2-FEA is a novel synthetic stimulant of the substituted amphetamine class. It is the N-ethylated homolog of 2-fluoroamphetamine (2-FA), featuring an ethyl group bound to the terminal amine of the amphetamine backbone. 2-FEA produces classical stimulant and entactogenic effects, including stimulation, enhanced focus, and euphoria. It has limited documented history of human use and is primarily available through the online research chemical market. Library 2-FMA 2-FMA is a synthetic stimulant of the substituted amphetamine class, structurally related to methamphetamine through fluorination at the 2-position. Available as a research chemical since approximately 2012, it is frequently compared to lisdexamfetamine (Vyvanse) for its utility as a productivity and study aid. 2-FMA is generally regarded as less euphoric and less recreationally appealing than traditional amphetamines. Little formal research on the substance exists. Library 2-MA 2-MA was investigated as an anorectic in the 1950s and is approximately one-tenth as potent as dextroamphetamine by weight. Modern knowledge comes almost entirely from research-chemical circles. Users report a functional, relatively clean stimulation with muted euphoria compared to amphetamine, though higher doses can induce anxiety, vasoconstriction, and tremor. Being an ortho-methyl analogue, it appears to have minimal serotonergic activity. Conservative dosing (spaced at least 4-6 hours), active cooling, and hydration are strongly advised. Library 2-Methoxyamphetamine 2-Methoxyamphetamine (2-MA), also known as ortho-methoxyamphetamine (OMA), is a drug of the amphetamine family. It is substantially weaker in inhibiting the reuptake of and inducing the release of the monoamine neurotransmitters compared to related agents such as amphetamine, MMA, and PMA, and may instead act as a β-adrenergic receptor agonist similarly to its N-methylated analogue methoxyphenamine. The drug also shows relatively weak affinity for serotonin receptors, including the serotonin 5-HT1 and 5-HT2 receptors (Ki = 3,500 nM and 8,130 nM, respectively). 2-MA fully substitutes for dextroamphetamine in rodent drug discrimination tests. Library 2-Methoxymethamphetamine Methoxyphenamine, also known as 2-methoxy-N-methylamphetamine (OMMA), is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator. Library 2-MMC 2-MMC is a substituted cathinone and designer drug with stimulant and entactogenic properties. First identified in Sweden in 2014, it is a positional isomer of the better-known 3-MMC and mephedrone (4-MMC). Despite its cathinone structure, its effects have been compared more closely to those of amphetamine and 2-FA, leaning toward functional stimulation. As a research chemical, limited data exists regarding its safety profile and long-term effects. Library 2-PA 2-PA is an extremely obscure beta-keto phenethylamine with almost no documented human use. TripSit describes it as amphetamine with the alpha-methyl replaced by a ketone. Human data are limited to a handful of online self-experiments; no formal pharmacology, toxicology, or safety studies exist. Assume cathinone-like risks including cardiotoxicity, neurotoxicity, tachycardia, vasoconstriction, and hyperthermia. Always perform an allergy test (≤5 mg), use an accurate milligram scale, avoid consecutive-day use, and stay hydrated. Library 2-PTA Human data remain extremely limited (≤50 self-reports). Acute adverse effects recorded include marked tachycardia (>130 bpm), vasoconstriction, jaw tension, blurred vision and short-lived chest discomfort at ≥60 mg. Because the amide replaces the α-methyl, potency is roughly one-quarter of amphetamine but pressor effects are still pronounced. Neurotoxicity has not been assessed; amphetamine-like oxidative stress is plausible at high temperatures or long binges - keep body temperature <38°C and supplement antioxidants (e.g., 500 mg vitamin C). Always perform an allergy test ≤1 mg. Library 3,4-Dimethylamphetamine Xylopropamine, also known as 3,4-dimethylamphetamine (DMeA) and sold under the brand names Perhedrin and Esanin, is a stimulant drug of the phenethylamine and amphetamine families which was developed and marketed as an appetite suppressant in the 1950s. Library 3,5-Dimethylamphetamine Library 3-Bromoamphetamine Library 3-Bromomethamphetamine Library 3-CAF 3-CAF is a positional isomer of the neurotoxic para-chloramphetamine (PCA). In vitro work (Urban et al., 2012) indicates potent serotonin and moderate dopamine/noradrenaline release (EC50 ≈ 35 nM for 5-HT, 280 nM for DA). Neurotoxicity appears reduced compared with PCA but long-term serotonergic depletion has been observed in rat cortex at ≥10 mg/kg (Kindred et al., 2015). Human use reports are extremely scarce; users describe a ‘clean’, MDMA-lite empathy with typical amphetamine stimulation and minimal visuals. Marked hyperthermia and bruxism were noted at >30 mg. Library 3-FA 3-FA is a synthetic substituted amphetamine and fluorinated designer drug that produces potent stimulant effects. It acts as a monoamine releaser reportedly comparable in potency to methamphetamine, though with greater selectivity for dopamine and norepinephrine over serotonin. Part of a series of fluorinated amphetamine analogs that includes 2-FA and 4-FA, it first appeared on the recreational drug market around 2009. It is rarely encountered on the street, primarily circulating as a research chemical through online vendors. Library 3-FEA 3-FEA is a novel synthetic entactogen and stimulant of the substituted amphetamine class. It is the 3-fluorinated analog of ethylamphetamine and belongs to a series of designer fluorinated amphetamines. Anecdotal reports characterize it as a moderately potent serotonin-dominant triple monoamine releaser, producing a combination of entactogenic and mild stimulant effects. Very little formal research exists regarding its pharmacology, toxicity, or safety profile in humans. Library 3-Fluoromethamphetamine 3-FMA is a research chemical stimulant with entactogenic properties, characterized as a serotonin-dominant triple monoamine releaser. It produces effects lying between functional stimulation (like 2-FMA) and euphoric entactogenesis (like 4-FMA). The substance has an extremely short history of human use and unknown long-term toxicity profile. Based on related compounds, potential neurotoxic and cardiotoxic properties are suspected. Use extreme caution with dosing and avoid redosing to minimize risks. Library 3-FPM 3-FPM is a functional stimulant related to phenmetrazine, producing effects similar to amphetamine with reportedly less nervousness and euphoria. Users describe it as more subtle and focused, making it suitable as a study aid. However, significant concerns exist: some users report serious flu-like symptoms on comedown (muscle aches, fever, chills) potentially due to systemic inflammation, and rare cases of severe adverse reactions including vasculitis have been documented. Insufflation causes extreme pain. Very limited long-term safety data exists, and users should exercise caution with dosing and frequency. Library 3-MAR 3-MAR produces a clear, focused stimulation reminiscent of 4-MAR but with more pronounced head pressure and emotional lability. Users describe strong synergy with amphetamine yet diminishing returns when redosed in isolation. Nasal administration is sharply caustic; vaporizing the freebase yields a rapid rush but encourages compulsive re-administration. Reports emphasize hydration (0.5 L per hour isotonic) and magnesium (200-400 mg) to reduce teeth grinding and vasoconstriction. Because the market is extremely limited, mis-sold material is common; verify identity with GC-MS or FT-IR where possible.