For serotonin syndrome management: administer a 12 mg oral loading dose, then 2 mg every 2 hours until clinical improvement (max 32 mg/24 hours); thereafter give 4-8 mg every 6 hours as needed. Monitor for over-sedation, urinary retention, delirium, and hepatic enzymes in prolonged courses. May interfere with hemostasis and prolong bleeding time. Not approved for use in newborns or premature infants.
سيبروهيبتادين molecular structure diagram from the DrugsPRO substance library.
Also known as: Reactin, Apeplus, Biohept, Periatin, Periactin, Peritol, Ciplactin, Cyprodine, Cyproheptadinum
Classification
Chemical: Medicine
Psychoactive: Depressant
Tag: Antihistamine
Tag: Sedative
Tag: Tricyclic benzocycloheptene
Effects
Sedation
Appetite Stimulation
Dry Mouth
Antipruritic Relief
Motor Coordination Suppression
Muscle Relaxation
Drowsiness
Relaxation
Cognitive Impairment
Calmness
Increased Appetite
Confusion
Blurred Vision
Dulled Perception
Auditory Hallucination
Cognitive Dysphoria
Perception Of Bodily Heaviness
Auditory Distortion
Routes of Administration
Oral
Dosage
Threshold: 2-4 mg
Light: 4-8 mg
Common: 8-16 mg
Strong: 16-24 mg
Heavy: 24-32 mg
Duration
Onset: 0.5-1 h
Comeup: 1-3 h
Peak: 2-6 h
Offset: 2-4 h
After Effects: 24 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Cyproheptadine - دليل المواد DrugsPRO
Cyproheptadine: For serotonin syndrome management: administer a 12 mg oral loading dose, then 2 mg every 2 hours until clinical improvement (max 32 mg/24 hours); thereafter give 4-8 mg every 6 hours as needed. Monitor for over-sedation, urinary retention, delirium, and hepatic enzymes in prolonged c