Quetiapine is a second-generation atypical antipsychotic of the dibenzothiazepine class, structurally related to clozapine. Developed by AstraZeneca and first approved by the FDA in 1997, it is prescribed for schizophrenia, bipolar disorder, and as an adjunct in major depressive disorder. It is also widely used off-label for insomnia, anxiety, and other conditions. While recreational use is uncommon, reports of misuse have emerged, primarily driven by its sedative and anxiolytic properties.
Кветиапин molecular structure diagram from the DrugsPRO substance library.
Also known as: Derin, Seroquel, Xeroquel, Ketilept, Ketipinor
Classification
Chemical: Medicine
Psychoactive: Depressant
Tag: Antipsychotic
Tag: Dibenzothiazepine
Tag: Dibenzothiazepine derivative
Tag: Pharmaceutical
Effects
Sedation
Headache
Fatigue
Dry Mouth
Increased Blood Pressure
Akathisia Like Movement
Thought Deceleration
Emotion Suppression
Information Processing Suppression
Language Suppression
Amnesia
Anxiety Suppression
Dehydration
Appetite Change
Entity Imagery
Open Eye Visuals
Voices
Internal Hallucination
Routes of Administration
Oral
Dosage
Heavy: 300-800 mg
Light: 25-100 mg
Common: 100-400 mg
Strong: 400 mg
Threshold: 10 mg
Duration
Onset: 0.33-0.67 h
Peak: 1.5-6 h
Offset: 6-7 h
After Effects: 24-48 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Quetiapine - DrugsPRO ръководство за вещества
Quetiapine: Quetiapine is a second-generation atypical antipsychotic of the dibenzothiazepine class, structurally related to clozapine. Developed by AstraZeneca and first approved by the FDA in 1997, it is prescribed for schizophrenia, bipolar disorder, and as an adjunct in major depressive disorder