Formerly marketed for short-term (12 weeks) weight loss as Tenuate/Tepanil. EMA recommended withdrawal in 2022 due to pulmonary hypertension and valvular heart disease risk. Functions as prodrug to ethcathinone, a preferential norepinephrine releaser with weaker dopaminergic activity. Contraindicated in uncontrolled hypertension, cardiovascular disease, hyperthyroidism, glaucoma, severe anxiety, or history of substance abuse. Rapid tolerance develops with daily use.
Diethylpropion molecular structure diagram from the DrugsPRO substance library.
Also known as: Tenuate, Tepanil, Regenon, Amfepramone, Tenuate dospan, Diethylcathinone, Nobesine, Amfepramon, Phepranon, Regibon, Neobes, Préfamone
Classification
Chemical: Cathinone
Chemical: Medicine
Chemical: Phenethylamine
Psychoactive: Stimulant
Tag: Habit-Forming
Tag: Pharmaceutical
Effects
Increased Energy
Stimulation
Dry Mouth
Sweating
Increased Heart Rate
Elevated Blood Pressure
Increased Focus
Motivation Enhancement
Talkativeness
Euphoria
Anxiety
Irritability
Appetite Suppression
Light Sensitivity
Routes of Administration
Oral
Dosage
Threshold: 10 mg
Light: 25-50 mg
Common: 50-100 mg
Strong: 100-150 mg
Heavy: 150 mg +
Duration
Onset: 0.66-1.5 h
Comeup: 0.5-1 h
Peak: 1.5-4 h
Offset: 1-2 h
After Effects: 7-10 h
Total Duration: 6-8 h
Insufflated
Dosage
Threshold: 5 mg
Light: 10-20 mg
Common: 20-40 mg
Strong: 40-60 mg
Heavy: 60 mg +
Duration
Onset: 0.08-0.25 h
Comeup: 0.25-0.5 h
Peak: 1-2 h
Offset: 1-2 h
After Effects: 1-3 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Diethylpropion - DrugsPRO průvodce látkou
Diethylpropion: Formerly marketed for short-term (12 weeks) weight loss as Tenuate/Tepanil. EMA recommended withdrawal in 2022 due to pulmonary hypertension and valvular heart disease risk. Functions as prodrug to ethcathinone, a preferential norepinephrine releaser with weaker dopaminergic activity
