Baclofen

Baclofen is a depressant and muscle relaxant of the butyric acid class that acts as a GABA-B receptor agonist. Originally synthesized in 1962 to treat epilepsy, it proved ineffective for that purpose but was later approved in 1977 for managing muscle spasticity. Chemically related to phenibut, pregabalin, and gabapentin, it produces sedation, anxiety suppression, and moderate euphoria. It has also been researched as a potential treatment for alcohol dependence.

Also known as: Liofen, Ozobax, Kemstro, Lioresal, Gablofen

Classification

Chemical: Gabapentinoid
Chemical: Medicine
Psychoactive: Depressant
Tag: Anxiolytic
Tag: Butyric acid
Tag: GABA analogue
Tag: GABAergic
Tag: Habit-Forming
Tag: Muscle Relaxant
Tag: Pharmaceutical
Tag: Sedative

Effects

Respiratory Depression
Sedation
Muscle Relaxation
Physical Fatigue
Nausea
Headache
Anxiety Suppression
Euphoria
Memory Suppression
Focus Suppression
Motor Control Loss
Dizziness
Dulled Perception
Disinhibition
Increased Libido
Spatial Disorientation
Dehydration
Open Eye Visuals

Routes of Administration

Oral

Dosage

Heavy: 75-125 mg
Light: 5 – 20 mg
Common: 20 – 50 mg
Strong: 50 – 75 mg
Threshold: 5 mg

Duration

Onset: 0.25-1.25 h
Comeup: 1-1.5 h
Peak: 1-2 h
Offset: 1.5-2.5 h
After Effects: 6-12 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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