HXE (3-HO-2'-Oxo-PCE) is a novel dissociative substance of the arylcyclohexylamine class that produces ketamine-like effects. Structurally related to methoxetamine, ketamine, and PCE, it is distinguished by a hydroxy group on the phenyl ring in place of the methoxy group found in MXE. HXE first became available on the research chemical market in late 2020 after years of synthesis difficulties. Very limited data exists regarding its pharmacology, metabolism, and toxicity in humans.
HXE molecular structure diagram from the DrugsPRO substance library.
Also known as: Hydroxetamine, 3-hydroxy-2-oxo-pce, O-desmethyl methoxetamine
Classification
Chemical: Arylcyclohexylamine
Psychoactive: Dissociative
Tag: Hallucinogen
Effects
Sedation
Nausea
Numbness
Incoordination
Loss Of Balance
Physical Euphoria
Dissociation
Euphoria
Conceptual Thinking
Immersion Enhancement
Dizziness
Motor Control Loss
Disinhibition
Increased Music Appreciation
Visual Disconnection
Tactile Suppression
Optical Sliding
Visual Acuity Suppression
Routes of Administration
Oral
Dosage
Heavy: 130+ mg
Light: 30 – 60 mg
Common: 60 – 100 mg
Strong: 100 – 130 mg
Threshold: 10–20 mg
Duration
Onset: 0.33-1 h
Comeup: 0.5-1 h
Peak: 2-4 h
Offset: 3-6 h
After Effects: 1-12 h
Total Duration: 3-5 h
Sublingual
Dosage
Heavy: 130 mg
Light: 30 – 60 mg
Common: 60 – 100 mg
Strong: 100 – 130 mg
Threshold: 30 mg
Duration
Onset: 0.25-0.75 h
Comeup: 0.5-1 h
Peak: 2-4 h
Offset: 2-6 h
After Effects: 1-12 h
Insufflated
Dosage
Heavy: 120+ mg
Light: 20 – 40 mg
Common: 40 – 70 mg
Strong: 70 – 120 mg
Threshold: 5–10 mg
Duration
Onset: 0.08-0.33 h
Comeup: 0.33-0.67 h
Peak: 1.5-4 h
Offset: 2-4 h
After Effects: 2-12 h
Total Duration: 4-6 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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HXE - DrugsPRO substansvejledning
HXE: HXE (3-HO-2'-Oxo-PCE) is a novel dissociative substance of the arylcyclohexylamine class that produces ketamine-like effects. Structurally related to methoxetamine, ketamine, and PCE, it is distinguished by a hydroxy group on the phenyl ring in place of the methoxy group found in MXE. HXE first
