Library
IC-26
Methiodone replaces methadone's ketone with a sulfone bioisostere, preserving μ-agonism but with variable potency reported at approximately 0.5-1.0× methadone. Users describe a slow, maintenance-like warmth rather than sharp euphoria. The caustic powder is best administered in oral capsules or dilute solutions. Accumulates over successive days; wait at least 12 hours before redosing. QT prolongation risk is assumed comparable to methadone; ECG monitoring is advised for chronic use.
Also known as: Win 1161-3, Methiodone, 4-(ethanesulfonyl)-N,N-dimethyl-4,4-diphenylbutan-2-amine
Classification
- Chemical: Opioid
- Psychoactive: Depressant
- Tag: Diphenylheptane
- Tag: Research-Chemical
- Tag: Synthetic opioid
Effects
- Physical Euphoria
- Pain Relief
- Sedation
- Itchiness
- Respiratory Depression
- Pupil Constriction
- Anxiety Suppression
- Relaxation
- Motivation Enhancement
- Dream Suppression
- Euphoria
- Calmness
- Dulled Perception
- Decreased Libido
- Visual Acuity Suppression
Routes of Administration
Oral
Dosage
- Threshold: 5-10 mg
- Light: 10-30 mg
- Common: 30-80 mg
- Strong: 80-150 mg
- Heavy: 150+ mg
Duration
- Onset: 0.5-2 h
- Comeup: 1-3 h
- Peak: 2-6 h
- Offset: 6-12 h
- After Effects: 12-24 h
- Total Duration: 8-24 h
Rectal
Dosage
- Threshold: 3-8 mg
- Light: 8-25 mg
- Common: 25-70 mg
- Strong: 70-120 mg
- Heavy: 120+ mg
Duration
- Onset: 0.25-0.75 h
- Comeup: 0.5 h
- Peak: 2-6 h
- Offset: 6-12 h
- After Effects: 10-20 h
- Total Duration: 8-20 h
Insufflated (Very Caustic; Discouraged)
Dosage
- Threshold: 5-15 mg
- Light: 15-40 mg
- Common: 40-80 mg
- Strong: 80-120 mg
- Heavy: 120 mg
Duration
- Onset: 0.17-0.5 h
- Comeup: 0.33 h
- Peak: 2-6 h
- Offset: 6-12 h
- After Effects: 24 h
Insufflated
Dosage
- Heavy: 120+ mg
- Light: 15–40 mg
- Common: 40–80 mg
- Strong: 80–120 mg
- Threshold: 5–15 mg
Duration
- Onset: 0.17-0.5 h
- Peak: 1.5-4 h
- Offset: 4-10 h
- After Effects: 10-16 h
- Total Duration: 6-16 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
Links
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