Selegiline is a selective, irreversible MAO-B inhibitor at therapeutic doses (5-10 mg/day oral), used for Parkinson's disease and major depressive disorder. At higher doses (>20 mg/day), selectivity is lost and it inhibits both MAO-A and MAO-B, increasing risk of hypertensive crisis with tyramine-rich foods. The transdermal form (Emsam) is used for depression and has less dietary restriction at lower doses due to reduced first-pass metabolism. Metabolizes to L-methamphetamine and L-amphetamine, which may cause mild stimulant effects. Dangerous interactions with serotonergic drugs (SSRIs, SNRIs, TCAs, MDMA, tramadol) and certain opioids (meperidine).
Selegilin molecular structure diagram from the DrugsPRO substance library.
Also known as: Emsam, Jumex, Zelapar, Anipryl, Deprenyl
Classification
Chemical: Amphetamine
Chemical: Medicine
Psychoactive: Nootropic
Psychoactive: Stimulant
Tag: Antidepressant
Tag: Pharmaceutical
Tag: Propargylamine
Effects
Stimulation
Insomnia
Increased Heart Rate
Reduced Fatigue
Slight Appetite Suppression
Physical Fatigue Reduction
Motivation Enhancement
Cognitive Enhancement
Focus Enhancement
Memory Enhancement
Mood Lift
Wakefulness
Libido Enhancement
Light Sensitivity
Appetite Suppression
Increased Libido
Dehydration
Photophobia
Routes of Administration
Oral
Dosage
Threshold: 1 mg
Light: 2.5-5 mg
Common: 5-10 mg
Strong: 10-15 mg
Heavy: 20 mg
Duration
Onset: 1 h
Comeup: 1-2 h
Peak: 1-2 h
After Effects: 2 h
Transdermal
Dosage
Threshold: 2 mg/24 h (continuous delivery via patch)
Light: 24 mg
Common: 24 mg
Strong: 24 mg
Heavy: 18 mg/24 h
Duration
Comeup: 6-12 h
Peak: 6-12 h
After Effects: 2 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
This static page is intended as a readable non-JS and prerender-friendly library export.
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Selegiline - DrugsPRO substansvejledning
Selegiline: Selegiline is a selective, irreversible MAO-B inhibitor at therapeutic doses (5-10 mg/day oral), used for Parkinson's disease and major depressive disorder. At higher doses (>20 mg/day), selectivity is lost and it inhibits both MAO-A and MAO-B, increasing risk of hypertensive crisis with
