2C-I is a synthetic phenethylamine psychedelic and member of the 2C-x family, a group of compounds derived through systematic modifications of mescaline. Alexander Shulgin synthesized it in 1976 and included it in PiHKAL, published in 1991. Often compared to 2C-B though less widely used, 2C-I gained popularity as a recreational psychedelic in the late 1990s. It is sometimes confused with the more dangerous analog 25I-NBOMe.
Also known as: 25i, Smiles, Wizard, N-bomb, Cimbi-5, NBOMe-2C-I, 2C-I-NBOMe
Classification
Chemical: Phenethylamine
Psychoactive: Psychedelic
Tag: 2C-X
Tag: Common
Tag: Hallucinogen
Tag: NBOMe
Tag: Research-Chemical
Tag: Substituted phenethylamine
Effects
Spontaneous Tactile Sensations
Stimulation
Vasoconstriction
Nausea
Physical Euphoria
Headache
Introspection
Thought Acceleration
Ego Suppression Loss And Death
Time Distortion
Conceptual Thinking
Thought Connectivity
Hallucinations
Visual Drifting
Tracers
After Images
Increased Visual Acuity
External Hallucination
Routes of Administration
Sublingual
Dosage
Heavy: >900–1000 µg (strongly discouraged)
Light: 50 – 500 µg
Common: 500 – 700 µg
Strong: 700 – 1000 µg
Threshold: 100–200 µg
Duration
Onset: 0.25-0.75 h
Comeup: 0.5-2 h
Peak: 2-4 h
Offset: 1-4 h
After Effects: 8-24 h
Total Duration: 6-11 h
Insufflated
Dosage
Heavy: 900 ug
Light: 50 – 400 µg
Common: 400 – 700 µg
Strong: 700 – 900 µg
Threshold: 50–100 µg
Duration
Onset: 0.1-0.2 h
Comeup: 0.17-0.5 h
Peak: 1-2 h
Offset: 2-3 h
After Effects: 6-24 h
Total Duration: 3-8 h
Oral
Dosage
Heavy: 30 mg
Light: 2 – 10 mg
Common: 10 – 20 mg
Strong: 20 – 30 mg
Threshold: 2 mg
Duration
Onset: 0.33-1.5 h
Comeup: 0.5-1 h
Peak: 3-5 h
Offset: 1-2 h
After Effects: 4-12 h
Buccal
Dosage
Heavy: >900–1000 µg (strongly discouraged)
Light: 200–400 µg
Common: 400–700 µg
Strong: 700–900 µg
Threshold: 100–200 µg
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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25I-NBOMe - DrugsPRO Substanzleitfaden
25I-NBOMe: 2C-I is a synthetic phenethylamine psychedelic and member of the 2C-x family, a group of compounds derived through systematic modifications of mescaline. Alexander Shulgin synthesized it in 1976 and included it in PiHKAL, published in 1991. Often compared to 2C-B though less widely used,
