4-CMC is a synthetic stimulant and entactogen of the substituted cathinone class. It has been sold online as a designer drug, often marketed as an alternative to mephedrone in regions where that substance was scheduled, reportedly producing broadly similar effects. Notably, 4-CMC is the cathinone analogue of 4-CMA, a compound associated with significant neurotoxicity, though it remains unclear whether 4-CMC carries the same risk.
Also known as: Clephedrone, 4-chloromethcathinone, 4-Cl-MC, P-Chloromethcathinone
Classification
Chemical: Cathinone
Psychoactive: Entactogen
Psychoactive: Stimulant
Tag: Habit-Forming
Tag: Research-Chemical
Effects
Increased Heart Rate
Increased Blood Pressure
Stimulation
Increased Bodily Temperature
Increased Perspiration
Teeth Grinding
Euphoria
Anxiety
Irritability
Sociability Enhancement
Wakefulness
Increased Sociability
Increased Libido
Appetite Suppression
Auditory Hallucination
External Hallucination
Increased Sexuality
Visual And Auditory Hallucinations
Routes of Administration
Oral
Dosage
Light: 30 – 50 mg
Common: 50-100 mg
Strong: 100-150 mg
Threshold: 20-30 mg
Heavy: 150+ mg
Duration
Onset: 0.33-1 h
Peak: 1-3 h
Offset: 3-5 h
After Effects: 6-24 h
Total Duration: 4-7 h
Insufflated
Dosage
Heavy: 100+ mg
Light: 15-30 mg
Common: 30-60 mg
Strong: 60-100 mg
Threshold: 5-15 mg
Duration
Onset: 0.02-0.08 h
Peak: 0.5-1.5 h
Offset: 1-2 h
After Effects: 2-24 h
Total Duration: 1-3 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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4-CMC - DrugsPRO Substanzleitfaden
4-CMC: 4-CMC is a synthetic stimulant and entactogen of the substituted cathinone class. It has been sold online as a designer drug, often marketed as an alternative to mephedrone in regions where that substance was scheduled, reportedly producing broadly similar effects. Notably, 4-CMC is the cathi
