Metabolizes to 4-fluoroamphetamine and 4-fluoromethamphetamine, which may add dopaminergic load and extend duration. Risk of serotonin syndrome when combined with serotonergic drugs. At higher doses (>10 mg) selectivity for MAO-B diminishes, increasing dietary tyramine risk and potential for non-selective MAO inhibition. Use accurate mg-scale for dosing. Contraindicated in individuals with cardiovascular disease.
Also known as: Fludepryl, Sr-96516-a, Chinoin-175, P-f-deprenyl, P-fluoro-l-deprenyl, 4‑Fluoroselegiline, P‑Fluoroselegiline, PFSL, 4‑F‑Deprenyl
Classification
Chemical: Amphetamine
Psychoactive: Nootropic
Psychoactive: Stimulant
Tag: Eugeroic
Tag: Propargylamine
Tag: Research-Chemical
Effects
Stimulation
Physical Fatigue Reduction
Insomnia
Fatigue
Loss Of Appetite
Dry Mouth
Euphoria
Focus Enhancement
Motivation Enhancement
Wakefulness
Sociability Enhancement
Thought Acceleration
Appetite Suppression
Increased Libido
Light Sensitivity
Libido Enhancement
Dehydration
Photophobia
Routes of Administration
Oral
Dosage
Threshold: 0.5 mg
Light: 1-2 mg
Common: 2-5 mg
Strong: 5-10 mg
Heavy: 10+ mg
Duration
Onset: 0.5-1 h
Comeup: 1-2 h
Peak: 2-4 h
Offset: 4-8 h
After Effects: 24-48 h
Total Duration: 4-8 h
Sublingual
Dosage
Threshold: 0.25 mg
Light: 0.5-1 mg
Common: 1-3 mg
Strong: 3-6 mg
Heavy: 6+ mg
Duration
Onset: 0.25-0.75 h
Comeup: 0.5-1.5 h
Peak: 1.5-3.5 h
Offset: 4-8 h
After Effects: 24-48 h
Total Duration: 4-8 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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4-Fluorodeprenyl - DrugsPRO Substanzleitfaden
4-Fluorodeprenyl: Metabolizes to 4-fluoroamphetamine and 4-fluoromethamphetamine, which may add dopaminergic load and extend duration. Risk of serotonin syndrome when combined with serotonergic drugs. At higher doses (>10 mg) selectivity for MAO-B diminishes, increasing dietary tyramine risk and pot
