DrugsPRO / Library / Gaboxadol

Library

Gaboxadol

Gaboxadol (THIP) is a direct-acting GABA-A receptor agonist developed by Lundbeck and Merck as an experimental sleep aid. Clinical trials were discontinued in 2007 due to narrow therapeutic index and psychiatric side effects at effective doses. Unlike benzodiazepines, it acts as an orthosteric agonist at the GABA binding site with preferential activity at extrasynaptic δ subunit-containing receptors. At low doses produces sedation and sleep enhancement; at higher doses produces distinctive hallucinogenic and deliriant effects. Not approved for medical use.

Gaboxadol molecular structure
Gaboxadol molecular structure diagram from the DrugsPRO substance library.

Also known as: Thip, Ov101, Mk-0928, Lu-2-030, Lu-02-030

Classification

  • Chemical: Medicine
  • Psychoactive: Deliriant
  • Psychoactive: Depressant
  • Tag: 3-Hydroxyisoxazole
  • Tag: Atypical Hallucinogen
  • Tag: GABAergic
  • Tag: Hallucinogen
  • Tag: Oneirogen
  • Tag: Research-Chemical
  • Tag: Sedative

Effects

  • Sedation
  • Sleepiness
  • Muscle Relaxation
  • Anxiolysis
  • Pain Relief
  • Nausea
  • Cognitive Euphoria
  • Dream Potentiation
  • Perspective Distortion
  • Memory Suppression
  • Consciousness Disconnection
  • Empathy Enhancement
  • Auditory Hallucination
  • External Hallucination
  • Internal Hallucination
  • Visual Distortion
  • Color Shifting
  • Increased Music Appreciation

Routes of Administration

Oral

Dosage

  • Threshold: 5 mg
  • Light: 5-10 mg
  • Common: 10-20 mg
  • Strong: 20-30 mg
  • Heavy: 30+ mg

Duration

  • Onset: 0.25-1 h
  • Comeup: 0.5-1 h
  • Peak: 1-2 h
  • Offset: 0-0.1 h
  • After Effects: 6-12 h
  • Total Duration: 4-8 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

This static page is intended as a readable non-JS and prerender-friendly library export.

Interactive library page More substances Sitemap index

Get the full DrugsPRO experience

Open the interactive DrugsPRO app for search, saved items, interactions, and deeper harm reduction tools.

Get the PRO test kit. The simple, quick and reliable drug checking test kit. Visit https://protestkit.eu

Get it on Google Play Download on the App Store

Gaboxadol - DrugsPRO Substanzleitfaden

Gaboxadol: Gaboxadol (THIP) is a direct-acting GABA-A receptor agonist developed by Lundbeck and Merck as an experimental sleep aid. Clinical trials were discontinued in 2007 due to narrow therapeutic index and psychiatric side effects at effective doses. Unlike benzodiazepines, it acts as an orthos

Related pages