4-AcO-DMT is a synthetic psychedelic of the tryptamine class, first synthesized by Albert Hofmann and Franz Troxler in 1963 during a chemical investigation into psilocin analogs. It is the acetylated form of psilocin and is widely believed to act as a prodrug for it, much like psilocybin. Its effects are frequently described as nearly indistinguishable from those of psilocybin mushrooms, though sometimes characterized as warmer or more euphoric. It has a limited history of human use.
Also known as: 4-aco, Psilacetin, 4-acetoxy-dmt, O-acetylpsilocin, Synthetic mushrooms
Classification
Chemical: Tryptamine
Psychoactive: Psychedelic
Tag: Common
Tag: Research-Chemical
Tag: substituted tryptamine
Effects
Spontaneous Tactile Sensations
Sedation
Creativity Enhancement
Excessive Yawning
Pupil Dilation
Runny Nose
Time Distortion
Dejavu
Feelings Of Predeterminism
Conceptual Thinking
Ego Suppression Loss And Death
Feelings Of Interdependent Opposites
Hallucinations
Visual Drifting
Tracers
After Images
Color Shifting
Scenery Slicing
Routes of Administration
Oral
Dosage
Heavy: 40-50+ mg
Light: 5 – 15 mg
Common: 15 – 25 mg
Strong: 25 – 40 mg
Threshold: 2.5-5 mg
Duration
Onset: 0.33-0.67 h
Comeup: 0.5-1.25 h
Peak: 2-3.5 h
Offset: 1-2 h
After Effects: 4-48 h
Total Duration: 4-8 h
Insufflated
Dosage
Heavy: 35-45+ mg
Light: 2 – 10 mg
Common: 10 – 20 mg
Strong: 20 – 25 mg
Threshold: 2.5-5 mg
Duration
Onset: 0.08-0.25 h
Comeup: 0.5-1 h
Peak: 1.5-2.5 h
Offset: 1-1.5 h
After Effects: 5-8 h
Total Duration: 3.5-7 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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4-AcO-DMT - Οδηγός ουσίας DrugsPRO
4-AcO-DMT: 4-AcO-DMT is a synthetic psychedelic of the tryptamine class, first synthesized by Albert Hofmann and Franz Troxler in 1963 during a chemical investigation into psilocin analogs. It is the acetylated form of psilocin and is widely believed to act as a prodrug for it, much like psilocybin.
