4-EPD is a ring-ethyl analogue of pentedrone first detected in European drug-checking samples in 2018. Toxicological information is sparse; a handful of fatal intoxications have been documented, usually with poly-drug use. Acute risks mirror those of other potent cathinones: tachycardia, hypertension, hyperthermia, rhabdomyolysis, hyponatremia from excessive water intake, acute psychosis, and serotonin syndrome when mixed with serotonergics. Weigh doses on a 0.001 g scale and perform an allergy test under 2 mg. Redosing markedly prolongs stimulation and increases vasoconstriction—limit to one redose if at all.
Also known as: P-epd, 4-ethylpentedrone, Para-ethyl pentedrone, 4-ethyl-alpha-methylamino-valerophenone
Classification
Chemical: Cathinone
Psychoactive: Stimulant
Tag: Habit-Forming
Tag: Research-Chemical
Tag: Tentative
Effects
Stimulation
Increased Heart Rate
Elevated Blood Pressure
Teeth Grinding
Vasoconstriction
Euphoria
Motivation Enhancement
Increased Sociability
Focus Enhancement
Empathy Enhancement
Anxiolysis Or Anxiety
Appetite Suppression
Tactile Enhancement
Disinhibition
Light Sensitivity
Routes of Administration
Oral
Dosage
Threshold: 10 mg
Light: 15-30 mg
Common: 30-60 mg
Strong: 60-90 mg
Heavy: 90 mg
Duration
Onset: 0.33-0.75 h
Peak: 0.5-1.5 h
Offset: 1-2 h
After Effects: 2-8 h
Insufflated
Dosage
Threshold: 5 mg
Light: 10-20 mg
Common: 20-35 mg
Strong: 35-50 mg
Heavy: 50 mg
Duration
Onset: 0.08-0.5 h
Peak: 0.5-1.5 h
Offset: 1-2 h
After Effects: 2-8 h
Rectal
Dosage
Threshold: 8 mg
Light: 12-25 mg
Common: 25-45 mg
Strong: 45-70 mg
Heavy: 70 mg
Duration
Onset: 0.08-0.25 h
Peak: 0.5-1.5 h
Offset: 1-2 h
After Effects: 2-8 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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4-EPD - Οδηγός ουσίας DrugsPRO
4-EPD: 4-EPD is a ring-ethyl analogue of pentedrone first detected in European drug-checking samples in 2018. Toxicological information is sparse; a handful of fatal intoxications have been documented, usually with poly-drug use. Acute risks mirror those of other potent cathinones: tachycardia, hype
