Hydromorphone is a semisynthetic opioid of the morphinan class, derived as a hydrogenated ketone of morphine. First introduced to the mass market in 1926 under the brand name Dilaudid, it is prescribed for the management of moderate to severe pain. Hydromorphone is notably more potent than morphine and carries a high potential for addiction and dependence. It has low oral bioavailability and is most commonly administered intravenously in clinical settings.
Υδρομορφόνη molecular structure diagram from the DrugsPRO substance library.
Also known as: Exalgo, Dilaudid, Jurnista, Diluadid, Palladone, Hydromorph-Contin, Dimorphone, Dihydromorphinone, Hydromorphonum, Hidromorfona, Idromorfone
Classification
Chemical: Medicine
Chemical: Morphinan
Chemical: Opioid
Psychoactive: Depressant
Tag: Habit-Forming
Tag: Sedative
Tag: substituted morphinan
Effects
Pain Relief
Cough Suppression
Respiratory Depression
Pupil Constriction
Decreased Blood Pressure
Decreased Heart Rate
Euphoria
Thought Deceleration
Cognitive Fatigue
Dizziness
Mood Lift
Anxiety Suppression
Cognitive Dysphoria
Auditory Enhancement
Brightness Enhancement
Increased Music Appreciation
Dulled Perception
Decreased Libido
Routes of Administration
Oral
Dosage
Heavy: 8+ mg
Light: 0.5 – 2 mg
Common: 2 – 4 mg
Strong: 4 – 8 mg
Threshold: 0.5 mg
Duration
Onset: 0.25-0.5 h
Comeup: 1-2 h
Peak: 0.25-0.33 h
Offset: 0.5-1 h
After Effects: 1-12 h
Total Duration: 3-6 h
Insufflated
Dosage
Heavy: 8+ mg
Light: 1 – 2 mg
Common: 2 – 4 mg
Strong: 4 – 8 mg
Threshold: 0.5 mg
Duration
Onset: 0.08-0.25 h
Comeup: 0.1-0.2 h
Peak: 0.25-0.75 h
Offset: 0.25-0.5 h
After Effects: 3.5-6 h
Total Duration: 3-5 h
Intravenous
Dosage
Heavy: 6+ mg
Light: 1 – 2 mg
Common: 2 – 4 mg
Strong: 4 – 6 mg
Threshold: 0.2 mg
Duration
Onset: 0.07-0.08 h
Comeup: 0.17-0.33 h
Peak: 0.17-0.33 h
Offset: 1.5-3 h
After Effects: 1-2 h
Total Duration: 2-4 h
Rectal
Dosage
Heavy: 6+ mg
Light: 1–2 mg
Common: 2–4 mg
Strong: 4–6 mg
Threshold: 0.5 mg
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Hydromorphone - Οδηγός ουσίας DrugsPRO
Hydromorphone: Hydromorphone is a semisynthetic opioid of the morphinan class, derived as a hydrogenated ketone of morphine. First introduced to the mass market in 1926 under the brand name Dilaudid, it is prescribed for the management of moderate to severe pain. Hydromorphone is notably more potent
