Library
O-DSMT
O-Desmethyltramadol is an opioid analgesic and the primary active metabolite of tramadol. Since the 2010s, it has been available through the research chemical market as a standalone substance. It acts as a full agonist at the mu-opioid receptor with additional affinity for delta and kappa receptors, producing more typical opioid-like effects than its parent compound. It also exhibits some influence on monoaminergic systems.
Also known as: O-Desmethyltramadol, Odt, O-smt, Desmetramadol
Classification
- Chemical: Opioid
- Psychoactive: Depressant
- Tag: Habit-Forming
- Tag: Phenylpropylamine
- Tag: Research-Chemical
- Tag: Synthetic opioid
- Tag: Tentative
Effects
- Pain Relief
- Physical Euphoria
- Itchiness
- Respiratory Depression
- Cough Suppression
- Difficulty Urinating
- Cognitive Euphoria
- Anxiety Suppression
- Compulsive Redosing
- Euphoria
- Mood Lift
- Sadness
- Dulled Perception
- Blurred Vision
- Disinhibition
- Auditory Hallucination
- Internal Music
- Sound Amplification
Routes of Administration
Oral
Dosage
- Heavy: 100 mg
- Light: 10 – 25 mg
- Common: 25 – 50 mg
- Strong: 50 – 100 mg
- Threshold: 10 mg
Duration
- Onset: 0.33-1 h
- Comeup: 0.5-0.7 h
- Peak: 2-5 h
- Offset: 2-4 h
- After Effects: 6-14 h
- Total Duration: 4-8 h
Intravenous
Dosage
- Threshold: 5 mg
- Heavy: 50 mg
- Common: 12.5-25 mg
- Light: 5-12.5 mg
- Strong: 25-50 mg
Duration
- Onset: 0 h
- Peak: 2-5 h
- Offset: 2-4 h
- After Effects: 1-3 h
Sublingual
Dosage
- Threshold: 5 mg
- Heavy: 80 mg
- Common: 25-50 mg
- Light: 10-25 mg
- Strong: 50-80 mg
Duration
- Onset: 0.3-0.7 h
- Peak: 2-5 h
- Offset: 2-4 h
- After Effects: 1-3 h
Insufflated
Dosage
- Heavy: 50+ mg
- Light: 5-10 mg
- Common: 10-30 mg
- Strong: 30-50 mg
- Threshold: 2 mg
Duration
- Onset: 0.17-0.5 h
- Peak: 0.75-2 h
- Offset: 2-5 h
- After Effects: 5-12 h
- Total Duration: 3-6 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
Links
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