25H-NBOMe is the N-(2-methoxybenzyl) derivative of 2C-H. Compared with halogenated NBOMes (25I/25C/25B), it shows drastically weaker 5-HT2A potency (approximately 675-fold lower than 25I-NBOMe in vitro) and a pronounced adrenergic/vasoconstrictive profile. Because of low psychedelic potency, users may attempt multi-milligram doses, greatly increasing peripheral toxicity risk (tachycardia, hypertension, vasospasm). Very limited human data exists; serious adverse reactions (panic, chest pain, prolonged hypertension) have been reported. Use extreme caution with accurate milligram scales, start with allergy test (<0.25 mg), and avoid redosing.
Also known as: 25h, 2c-h-nbome, Nbome-2c-h, NBOMe-H
Classification
Chemical: Phenethylamine
Psychoactive: Psychedelic
Psychoactive: Stimulant
Tag: Hallucinogen
Tag: Precursor
Tag: Research-Chemical
Tag: Tentative
Effects
Stimulation
Mouth Numbing
Pupil Dilation
Increased Heart Rate
Increased Blood Pressure
Vasoconstriction
Thought Acceleration
Thought Deceleration
Analysis Enhancement
Conceptual Thinking
Anxiety
Paranoia
Perception Of Bodily Lightness
Visual Acuity Enhancement
Color Enhancement
Pattern Recognition Enhancement
Drifting
Internal Hallucination
Routes of Administration
Sublingual
Dosage
Threshold: 0.5 mg
Light: 1-3 mg
Common: 3-6 mg
Strong: 6-10 mg
Heavy: 10 mg + (NOT RECOMMENDED)
Duration
Onset: 0.25-0.75 h
Comeup: 0.5-1 h
Peak: 1-3 h
Offset: 2-4 h
After Effects: 4-12 h
Total Duration: 4-8 h
Insufflated
Dosage
Threshold: 0.2 mg
Light: 0.5-1.5 mg
Common: 1.5-3 mg
Strong: 3-5 mg
Heavy: 5 mg + (NOT RECOMMENDED)
Duration
Onset: 0.08-0.25 h
Comeup: 0.25-0.5 h
Peak: 0.5-2 h
Offset: 2-4 h
After Effects: 3-12 h
Total Duration: 3-8 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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25H-NBOMe - DrugsPRO substance guide
25H-NBOMe: 25H-NBOMe is the N-(2-methoxybenzyl) derivative of 2C-H. Compared with halogenated NBOMes (25I/25C/25B), it shows drastically weaker 5-HT2A potency (approximately 675-fold lower than 25I-NBOMe in vitro) and a pronounced adrenergic/vasoconstrictive profile. Because of low psychedelic poten
