Library
2-Bromo-4,5-MDMA
2-Bromo-4,5-MDMA is an extremely under-researched halogenated MDMA analog with almost no published human data. All dosage and duration information is extrapolated from limited animal pharmacology studies and scarce user reports. In vitro studies suggest markedly reduced SERT (serotonin transporter) affinity compared to MDMA while retaining NET and DAT activity, with modest 5-HT2B agonism. This profile indicates the compound may be less empathogenic and more stimulant-focused than MDMA. Halogen substitution can extend half-life and increase 5-HT2B receptor activation, potentially raising cardiac valvulopathy risk.
Also known as: 6-bromo-mdma, 2-br-4,5-mdma, 6-Br-MDMA
Classification
- Chemical: Amphetamine
- Psychoactive: Entactogen
- Psychoactive: Stimulant
- Tag: Habit-Forming
- Tag: MDxx
- Tag: Research-Chemical
Effects
- Stimulation
- Physical Euphoria
- Teeth Grinding
- Jaw Clenching
- Pupil Dilation
- Increased Perspiration
- Cognitive Euphoria
- Empathy Enhancement
- Sociability Enhancement
- Anxiety Suppression
- Anxiety
- Thought Acceleration
- Tactile Enhancement
- Increased Music Appreciation
- Disinhibition
- Dehydration
- Appetite Suppression
- Cognitive Dysphoria
Routes of Administration
Oral
Dosage
- Threshold: 15-25 mg
- Light: 40-70 mg
- Common: 70-120 mg
- Strong: 120-160 mg
- Heavy: 160 mg +
Duration
- Onset: 0.33-1 h
- Comeup: 0.5-1 h
- Peak: 1.5-3 h
- Offset: 2-3 h
- After Effects: 6-24 h
- Total Duration: 5-8 h
Insufflated
Dosage
- Threshold: 5-10 mg
- Light: 20-35 mg
- Common: 35-60 mg
- Strong: 60-90 mg
- Heavy: 90 mg +
Duration
- Onset: 0.08-0.25 h
- Comeup: 0.25-0.5 h
- Peak: 1.5-3 h
- Offset: 2-3 h
- After Effects: 6-24 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
Links
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