2-Me-DMT is a rarely studied Shulgin-synthesized tryptamine notable for pronounced auditory distortion and pitch-shifting effects beginning at moderate doses. Unlike classical psychedelics, it produces minimal to no visual effects but instead causes tactile enhancement and sexual stimulation. The 2-methyl substitution blocks MAO metabolism allowing oral activity, but also dramatically reduces affinity for 5-HT2A receptors responsible for classical psychedelic effects. Users report unpredictable dose-response; starting low and titrating upward on separate sessions is advised. Combining with MAOIs or stimulants increases physiological risk.
Also known as: 2,n,n-tmt, 2,n,n-trimethyltryptamine, 2-methyl-DMT
Classification
Chemical: Tryptamine
Psychoactive: Psychedelic
Psychoactive: Stimulant
Tag: Atypical Hallucinogen
Tag: Research-Chemical
Tag: Tentative
Effects
Physical Euphoria
Bodily Activation
Cognitive Stimulation
Mild Nausea
Dilated Pupils
Temperature Dysregulation
Mild Relaxation
Euphoria
Empathy
Insight
Change In Perception
Ego Softening
Auditory Pitch Shifting
Auditory Distortion
Tactile Enhancement
Sexual Enhancement
Tingling Sensations
Skin Alertness
Routes of Administration
Oral
Dosage
Threshold: 15 mg
Light: 30-50 mg
Common: 50-75 mg
Strong: 75-100 mg
Heavy: 100+ mg
Duration
Onset: 1-1.5 h
Peak: 1-3 h
Offset: 1-3 h
After Effects: 0.5-5 h
Total Duration: 4-6 h
Insufflated
Dosage
Threshold: 5 mg
Light: 5-15 mg
Common: 15-30 mg
Strong: 30-50 mg
Heavy: 50+ mg
Duration
Onset: 0.17-0.5 h
Peak: 1-3 h
Offset: 1-3 h
After Effects: 0.5-4 h
Total Duration: 3-6 h
Vaporized
Dosage
Threshold: 2 mg
Light: 2-5 mg
Common: 5-10 mg
Strong: 10-20 mg
Heavy: 20+ mg
Duration
Onset: 0-0.03 h
Peak: 0.08-0.25 h
Offset: 0.17-0.33 h
After Effects: 0.25-2 h
Total Duration: 0.25-1 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
This static page is intended as a readable non-JS and prerender-friendly library export.
Get the full DrugsPRO experience
Open the interactive DrugsPRO app for search, saved items, interactions, and deeper harm reduction tools.
Get the PRO test kit. The simple, quick and reliable drug checking test kit. Visit https://protestkit.eu
2-Me-DMT - DrugsPRO substance guide
2-Me-DMT: 2-Me-DMT is a rarely studied Shulgin-synthesized tryptamine notable for pronounced auditory distortion and pitch-shifting effects beginning at moderate doses. Unlike classical psychedelics, it produces minimal to no visual effects but instead causes tactile enhancement and sexual stimulati
