Very little human data exist. All dosage estimates are extrapolated from closely related cathinones such as pentedrone and pentylone, a handful of Reddit and Bluelight reports, and forensic potency modelling. Users describe rapid, clean stimulation with mild empathogenic warmth, stronger on dopamine and norepinephrine than serotonin. Significant cardiovascular strain including tachycardia and vasoconstriction, along with harsh comedowns, have been reported above approximately 60 mg oral. Because metabolic and toxicological profiles are unknown, start with allergy tests (5 mg or less) and avoid frequent redosing.
Also known as: 3,4-tmp, 3,4-trimethylenepentedrone, TMPD
Classification
Chemical: Cathinone
Psychoactive: Entactogen
Psychoactive: Stimulant
Tag: Habit-Forming
Tag: Research-Chemical
Effects
Stimulation
Teeth Grinding
Muscle Tension
Increased Perspiration
Vasoconstriction
Insomnia
Euphoria
Enhanced Sociability
Increased Motivation
Focus Enhancement
Anxiety
Cognitive Fatigue
Mild Tactile Enhancement
Appetite Suppression
Tactile Enhancement
Light Sensitivity
Increased Libido
Dehydration
Routes of Administration
Oral
Dosage
Threshold: 10-15 mg
Light: 15-30 mg
Common: 30-60 mg
Strong: 60-90 mg
Heavy: 90+ mg
Duration
Onset: 0.25-0.5 h
Comeup: 0.5-1 h
Peak: 1-2.5 h
Offset: 1-2 h
After Effects: 0.5-3 h
Total Duration: 3-6 h
Insufflated
Dosage
Threshold: 5-10 mg
Light: 10-20 mg
Common: 20-40 mg
Strong: 40-60 mg
Heavy: 60+ mg
Duration
Onset: 0.02-0.17 h
Comeup: 0.25-0.5 h
Peak: 0.5-1.5 h
Offset: 1.5-3 h
After Effects: 0.5-2 h
Total Duration: 2.5-5 h
Rectal
Dosage
Threshold: 7-12 mg
Light: 12-25 mg
Common: 25-45 mg
Strong: 45-70 mg
Heavy: 70+ mg
Duration
Onset: 0.17-0.33 h
Comeup: 0.33-0.67 h
Peak: 1-2.5 h
Offset: 1-2 h
After Effects: 0.5-3 h
Total Duration: 3-6 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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3,4-TMPD - DrugsPRO substance guide
3,4-TMPD: Very little human data exist. All dosage estimates are extrapolated from closely related cathinones such as pentedrone and pentylone, a handful of Reddit and Bluelight reports, and forensic potency modelling. Users describe rapid, clean stimulation with mild empathogenic warmth, stronger o
