4-Fluoropentedrone (4-FPD) is a synthetic cathinone sold on the gray market since approximately 2018. Human pharmacology remains largely uncharacterised; harm-reduction advice is extrapolated from pentedrone and 4-FMC data plus limited community reports. Acute risks include tachycardia, hypertension, vasoconstriction, hyperthermia, diaphoresis, agitation, bruxism, mydriasis, anxiety, and panic. Severe complications include rhabdomyolysis and serotonin-toxicity-like syndromes when combined with serotonergic agents. Purity varies widely in street samples; use reagent testing (Marquis: pale yellow to brown) and accurate milligram scales.
Also known as: 4-fpd, 4-f-pentedrone, 4-fluoro-alpha-methylamino-valerophenone
Classification
Chemical: Cathinone
Psychoactive: Stimulant
Tag: Habit-Forming
Tag: Research-Chemical
Tag: Tentative
Effects
Stimulation
Physical Euphoria
Increased Heart Rate
Increased Blood Pressure
Vasoconstriction
Increased Perspiration
Cognitive Euphoria
Motivation Enhancement
Focus Enhancement
Increased Sociability
Thought Acceleration
Anxiety
Disinhibition
Increased Music Appreciation
Appetite Suppression
Dehydration
Tactile Enhancement
Increased Libido
Routes of Administration
Oral
Dosage
Threshold: 10-20 mg
Light: 20-40 mg
Common: 40-80 mg
Strong: 80-120 mg
Heavy: 120+ mg
Duration
Onset: 0.17-0.5 h
Comeup: 0.25-0.5 h
Peak: 1-2 h
Offset: 1-2 h
After Effects: 2-6 h
Total Duration: 2-4 h
Insufflated
Dosage
Threshold: 5-10 mg
Light: 10-25 mg
Common: 25-60 mg
Strong: 60-90 mg
Heavy: 90+ mg
Duration
Onset: 0.03-0.08 h
Comeup: 0.08-0.17 h
Peak: 0.5-1.5 h
Offset: 1-2 h
After Effects: 2-6 h
Total Duration: 1.5-3 h
Rectal
Dosage
Threshold: 8-15 mg
Light: 15-30 mg
Common: 30-60 mg
Strong: 60-90 mg
Heavy: 90+ mg
Duration
Onset: 0.08-0.17 h
Comeup: 0.17-0.33 h
Peak: 0.75-1.5 h
Offset: 1-2 h
After Effects: 2-6 h
Total Duration: 1.5-3 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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4-Fluoropentedrone - DrugsPRO substance guide
4-Fluoropentedrone: 4-Fluoropentedrone (4-FPD) is a synthetic cathinone sold on the gray market since approximately 2018. Human pharmacology remains largely uncharacterised; harm-reduction advice is extrapolated from pentedrone and 4-FMC data plus limited community reports. Acute risks include tachy
