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Acetorphine

Acetorphine is an extremely potent synthetic opioid analgesic, up to 8700 times stronger than morphine by weight. It is a derivative of etorphine and was developed in 1966 by the Reckitt research group exclusively for veterinary immobilization of large animals such as elephants, giraffes, and rhinoceros. Despite showing some advantages over etorphine (reduced toxic side effects in giraffes), it was never widely adopted for veterinary use. Acetorphine is Schedule I in the United States and Class A in the UK, prohibited for human use. Human exposure can be fatal even at extremely low doses due to severe respiratory depression.

Acetorphine molecular structure
Acetorphine molecular structure diagram from the DrugsPRO substance library.

Also known as: Acetyletorphine, Acetylpropylorvinol, Acetorfina

Classification

  • Chemical: Morphinan
  • Chemical: Opioid
  • Psychoactive: Depressant
  • Tag: Habit-Forming
  • Tag: Oripavine derivative
  • Tag: Research-Chemical
  • Tag: Veterinary-only

Effects

  • Analgesia
  • Sedation
  • Respiratory Depression
  • Physical Euphoria
  • Nausea
  • Itchiness
  • Euphoria
  • Anxiety Suppression
  • Sadness
  • Reduced Anxiety
  • Cognitive Euphoria
  • Mood Lift
  • Dulled Perception
  • Decreased Libido
  • Increased Music Appreciation
  • Cognitive Dysphoria
  • Internal Hallucination
  • Closed Eye Visuals

Routes of Administration

Intramuscular

Dosage

  • Common: Veterinary use only: 0.01-0.03 mg per animal (large mammals)

Duration

No data available for this section yet.

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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Acetorphine - DrugsPRO substance guide

Acetorphine: Acetorphine is an extremely potent synthetic opioid analgesic, up to 8700 times stronger than morphine by weight. It is a derivative of etorphine and was developed in 1966 by the Reckitt research group exclusively for veterinary immobilization of large animals such as elephants, giraffe

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