Diphenoxylate is a centrally active opioid drug of the phenylpiperidine series that is used as a combination drug with atropine for the treatment of diarrhea. Diphenoxylate is an opioid and acts by slowing intestinal contractions; the atropine is present to prevent drug abuse and overdose. It should not be given to children due to the risk that they will stop breathing and should not be used in people with Clostridioides difficile infection.
Diphenoxylate molecular structure diagram from the DrugsPRO substance library.
Also known as: Diphenoxylate hydrochloride, Diphenoxylate HCl
Classification
Chemical: Medicine
Chemical: Opioid
Psychoactive: Depressant
Tag: Antidiarrheal
Effects
Sedation
Motor Impairment
Respiratory Depression
Constipation
Pupil Constriction
Itchiness
Reduced Anxiety
Euphoria
Anxiety Suppression
Dulled Perception
Routes of Administration
No route information available yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Diphenoxylate - DrugsPRO substance guide
Diphenoxylate: Diphenoxylate is a centrally active opioid drug of the phenylpiperidine series that is used as a combination drug with atropine for the treatment of diarrhea. Diphenoxylate is an opioid and acts by slowing intestinal contractions; the atropine is present to prevent drug abuse and over
