Library
Ibotenic acid
Ibotenic acid is a powerful neurotoxin and the primary psychoactive constituent of Amanita muscaria. It acts as a prodrug to muscimol, which produces most of the sedative and GABAergic effects. Upon ingestion, a portion of ibotenic acid is decarboxylated to muscimol in the body, while substantial amounts are excreted unchanged in urine. Ibotenic acid itself acts as a glutamate receptor agonist and may have stimulant-like properties distinct from muscimol's depressant effects. The compound is used extensively in neuroscience research as a brain-lesioning agent due to its excitotoxic properties.
Also known as: Ibotenate, Premuscimol, IBO
Classification
- Psychoactive: Deliriant
- Psychoactive: Dissociative
- Tag: 3-Hydroxyisoxazole
- Tag: Amino acid
- Tag: Atypical Hallucinogen
- Tag: GABAergic
- Tag: Hallucinogen
- Tag: Plant-based
- Tag: Research-Chemical
- Tag: Sedative
Effects
- Sedation
- Ataxia
- Nausea
- Muscle Twitching
- Vomiting
- Incoordination
- Confusion
- Delirium
- Drowsiness
- Disorientation
- Euphoria
- Retrograde Amnesia
- Visual Distortion
- Auditory Distortion
- Sensations Of Floating
- Open Eye Visuals
- Auditory Warping
- Warping
Routes of Administration
Oral
Dosage
- Threshold: ~30 mg
- Light: 30-50 mg
- Common: 50-100 mg
- Strong: 100-150 mg
- Heavy: 150+ mg
Duration
- Onset: 0.5-2 h
- Comeup: 1-2 h
- Peak: 2-4 h
- Offset: 2-4 h
- After Effects: 8-24 h
- Total Duration: 6-8 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
Links
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