Isotonitazepyne is approximately 1000 times more potent than morphine in vitro. Active doses are in the microgram range; volumetric dosing or pre-measured nasal spray formulations are essential. Counterfeit pharmaceutical pills (marketed as oxycodone) containing 3-4 mg per pill have caused multiple fatalities in Europe. Naloxone rescue may require multiple administrations due to prolonged receptor occupancy. Do not use alone; have naloxone immediately available.
Isotonitazepyne molecular structure diagram from the DrugsPRO substance library.
Also known as: Npi, Iso-pyne, N-pyrrolidino isotonitazene, Isotonitazepyne
Classification
Chemical: 2-Benzylbenzimidazole opioid
Chemical: Opioid
Psychoactive: Depressant
Tag: Benzimidazole
Tag: Habit-Forming
Tag: Nitazene
Tag: Research-Chemical
Effects
Physical Euphoria
Pain Relief
Sedation
Respiratory Depression
Itchiness
Muscle Relaxation
Cognitive Euphoria
Anxiety Suppression
Motivation Suppression
Compulsive Redosing
Sadness
Withdrawal
Internal Hallucination
Size Distortion
Dulled Perception
Warmth
Warm Flush
Appetite Suppression
Routes of Administration
Intranasal
Dosage
Threshold: 25 ug
Light: 25-100 ug
Common: 100-300 ug
Strong: 300-600 ug
Heavy: 600 ug
Duration
Onset: 0.08-0.25 h
Comeup: 0.08-0.17 h
Peak: 0.5-1.5 h
Offset: 1-2 h
After Effects: 1-3 h
Oral
Dosage
Threshold: 50 ug
Light: 50-150 ug
Common: 150-400 ug
Strong: 400-800 ug
Heavy: 800 µg+
Duration
Onset: 0.25-0.5 h
Comeup: 0.17-0.33 h
Peak: 0.5-1.5 h
Offset: 2-3.5 h
After Effects: 3.5-7 h
Total Duration: 3-6 h
Insufflated
Dosage
Heavy: 600 µg+
Light: 25–100 µg
Common: 100–300 µg
Strong: 300–600 µg
Threshold: 25 µg
Duration
Onset: 0.08-0.25 h
Peak: 0.5-1.5 h
Offset: 1.5-3 h
After Effects: 3-6 h
Total Duration: 3-5 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Isotonitazepyne - DrugsPRO substance guide
Isotonitazepyne: Isotonitazepyne is approximately 1000 times more potent than morphine in vitro. Active doses are in the microgram range; volumetric dosing or pre-measured nasal spray formulations are essential. Counterfeit pharmaceutical pills (marketed as oxycodone) containing 3-4 mg per pill have
