Methamphetamine is a potent synthetic stimulant of the substituted amphetamine class. First synthesized in 1893 by Japanese chemist Nagayoshi Nagai, it saw widespread use during World War II to combat fatigue and was later prescribed for obesity and attention deficit disorder under the brand name Desoxyn. Because it is more lipid-soluble than amphetamine, it enters the brain faster. Methamphetamine carries a significant risk of addiction and remains widely used as a street drug.
Methamphetamine molecular structure diagram from the DrugsPRO substance library.
Also known as: Ma, Ice, Tik, Meth, Tina, Crystal, Glass, Shards, Tweak, Crank, Shabu, Metamfetamine
Classification
Chemical: Amphetamine
Psychoactive: Stimulant
Tag: Common
Tag: Habit-Forming
Effects
Stimulation
Increased Heart Rate
Nausea
Frequent Urination
Abnormal Heartbeat
Vasoconstriction
Focus Enhancement
Ego Inflation
Wakefulness
Thought Acceleration
Analysis Enhancement
Memory Enhancement
Sexual Arousal
Dehydration
Appetite Suppression
Increased Sexuality
Visual And Audiotory Hallucinations Itchiness
Increased Libido
Routes of Administration
Oral
Dosage
Heavy: 40-100 mg
Light: 5 – 15 mg
Common: 15 – 30 mg
Strong: 30 – 60 mg
Threshold: < 5 mg
Bioavailability: 100 mg
Duration
Onset: 0.33-0.75 h
Comeup: 1-3 h
Peak: 3-5 h
Offset: 6-12 h
After Effects: 12-36 h
Total Duration: 8-12 h
Insufflated
Dosage
Heavy: 60+ mg
Light: 5 – 15 mg
Common: 15 – 30 mg
Strong: 30 – 60 mg
Threshold: < 5 mg
Bioavailability: >90%
Duration
Onset: 0.05-0.08 h
Comeup: 0.05-0.08 h
Peak: 1.5-3 h
Offset: 2-4 h
After Effects: 6-24 h
Total Duration: 2-6 h
Smoked
Dosage
Heavy: 60+ mg
Light: 5 – 15 mg
Common: 15 – 30 mg
Strong: 30 – 60 mg
Threshold: < 5 mg
Bioavailability: >90%
Duration
Onset: 0-0.03 h
Comeup: 0-0 h
Peak: 0.33-2 h
Offset: 1-3 h
After Effects: 2-24 h
Total Duration: 1-4 h
Rectal
Dosage
Heavy: 50 mg
Light: 5 – 15 mg
Common: 15 – 30 mg
Strong: 30 – 50 mg
Threshold: < 5 mg
Bioavailability: ~99% [2]
Duration
Onset: 0.08-0.25 h
Comeup: 0.05-0.08 h
Peak: 2-4 h
Offset: 3-5 h
After Effects: 6-24 h
Intravenous
Dosage
Heavy: 60+ mg
Light: 5 – 10 mg
Common: 10 – 30 mg
Strong: 30 – 60 mg
Threshold: 5 mg
Bioavailability: ~100% [1]
Duration
Onset: 0-0.01 h
Comeup: 0.02-0.03 h
Peak: 0.1-2 h
Offset: 2-4 h
After Effects: 6-24 h
Total Duration: 4-8 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Methamphetamine - DrugsPRO substance guide
Methamphetamine: Methamphetamine is a potent synthetic stimulant of the substituted amphetamine class. First synthesized in 1893 by Japanese chemist Nagayoshi Nagai, it saw widespread use during World War II to combat fatigue and was later prescribed for obesity and attention deficit disorder under
