Library

Naloxone

Naloxone (commonly sold under the brand names Narcan and Evzio) is a synthetic mu-opioid antagonist of the morphinan chemical class that is widely used to reverse the effects of an acute opioid overdose. Naloxone is sold under the brand name Narcan as a nasal spray and Evzio as an auto-injector with voice instructions.

Naloxone molecular structure
Naloxone molecular structure diagram from the DrugsPRO substance library.

Classification

  • Chemical: Morphinan
  • Chemical: Opioid
  • Tag: substituted morphinan
  • Tag: Opioid antagonist
  • Tag: Antidote

Effects

No data available for this section yet.

Routes of Administration

Insufflated

Dosage

  • Common: 1-4 mg

Duration

  • Onset: 0-0.2 h

Intramuscular

Dosage

  • Common: 0.4-2 mg

Duration

  • Onset: 0 h

Intravenous

Dosage

  • Common: 0.4-2 mg

Duration

  • Onset: 0 h

Oral

Dosage

  • Threshold: 4 mg
  • Heavy: 28 mg
  • Common: 8-16 mg
  • Light: 4-8 mg
  • Strong: 16-28 mg

Duration

  • Onset: 0.1-0.2 h
  • Comeup: 0.3-0.7 h
  • Peak: 1-2 h
  • Offset: 0.5-1 h
  • After Effects: 1-12 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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Naloxone - DrugsPRO substance guide

Naloxone: Naloxone (commonly sold under the brand names Narcan and Evzio) is a synthetic mu-opioid antagonist of the morphinan chemical class that is widely used to reverse the effects of an acute opioid overdose. Naloxone is sold under the brand name Narcan as a nasal spray and Evzio as an auto-inj

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