Community reports describe near-complete termination of LSD or psilocybin effects within ~30 min after a 5-10 mg orally-disintegrating dose, usually followed by deep sleep. Controlled studies show a single 10 mg IM injection quells acute agitation as effectively as haloperidol but with fewer extrapyramidal reactions. Orally-disintegrating formulations dissolve in under one minute and reach measurable plasma levels faster than standard tablets. Mean elimination half-life is ~30 h (range 21-54 h), explaining next-day lethargy. Case reports of ingestions >40 mg document coma, miotic pupils and hypoventilation—clinical presentation that can mimic opioid toxicity—managed with airway support and monitoring.
Olanzapine molecular structure diagram from the DrugsPRO substance library.
Also known as: Lanzac, Zyprexa, Olansek, Symbyax, Olanzapin, Zyprexa Zydis, LY170053
Classification
Chemical: Medicine
Psychoactive: Depressant
Tag: Antipsychotic
Tag: Pharmaceutical
Tag: Sedative
Tag: Thienobenzodiazepine
Tag: Trip-killer
Effects
Powerful Sedation
Anxiolysis
Dry Mouth
Sedation
Orthostatic Hypotension
Fatigue
Emotional Blunting
Increased Appetite
Nextday Grogginess
Motor Control Loss
Thought Loop
Anxiety Suppression
Cognitive Dysphoria
Open Eye Visuals
Dulled Perception
Dehydration
Appetite Change
Entity Imagery
Routes of Administration
Oral / Orally Disintegrating Tablet
Dosage
Threshold: 1-2 mg
Light: 2.5-5 mg
Common: 5-10 mg
Strong: 10-15 mg
Heavy: 15 mg
Duration
Onset: 0.25-0.75 h
Comeup: 0.5-1 h
Peak: 1-3 h
Offset: 4-8 h
After Effects: 18-24 h
Intramuscular (Clinical Setting)
Dosage
Threshold: 2.5 mg
Light: 5 mg
Common: 10 mg
Strong: 10-20 mg
Heavy: 20 mg
Duration
Onset: 0.25 h
Comeup: 0.25-0.5 h
Peak: 1-3 h
Offset: 4-8 h
After Effects: 18-24 h
Oral
Dosage
Heavy: 15+ mg
Light: 2.5-5 mg
Common: 5-10 mg
Strong: 10-15 mg
Threshold: 1-2 mg
Duration
No data available for this section yet.
Intramuscular
Dosage
Heavy: 20+ mg
Light: 5 mg
Common: 10 mg
Strong: 10-20 mg
Threshold: 2.5 mg
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Olanzapine - DrugsPRO substance guide
Olanzapine: Community reports describe near-complete termination of LSD or psilocybin effects within ~30 min after a 5-10 mg orally-disintegrating dose, usually followed by deep sleep. Controlled studies show a single 10 mg IM injection quells acute agitation as effectively as haloperidol but with f
