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Parafluorofentanyl

Parafluorofentanyl is an extremely potent synthetic opioid and analogue of fentanyl, originally developed by Janssen Pharmaceutica during the 1960s. It is classified as a depressant with significant habit-forming potential. The substance remains rare, and relatively little is known about its pharmacological profile or safety margins. Due to its exceptional potency, it should be handled with extreme caution, and combining it with other depressants is strongly discouraged due to the heightened risk of fatal respiratory depression.

Parafluorofentanyl molecular structure
Parafluorofentanyl molecular structure diagram from the DrugsPRO substance library.

Also known as: Pff, 4-fluorofentanyl, Parafluorofentanyl, p-fluorofentanyl

Classification

  • Chemical: Anilidopiperidine
  • Chemical: Opioid
  • Psychoactive: Depressant
  • Tag: Fentanyl analogue
  • Tag: Habit-Forming
  • Tag: Sedative
  • Tag: Tentative

Effects

  • Respiratory Depression
  • Itchiness
  • Nausea
  • Sedation
  • Motor Impairment
  • Constipation
  • Reduced Anxiety
  • Euphoria
  • Anxiety Suppression
  • Dizziness
  • Sadness
  • Cognitive Euphoria
  • Dulled Perception
  • Open Eye Visuals
  • Sound Dampening

Routes of Administration

Insufflated

Dosage

  • Heavy: 65 ug
  • Light: 10 – 25 µg
  • Common: 25 – 40 µg
  • Strong: 40 – 65 µg
  • Threshold: 10 ug

Duration

No data available for this section yet.

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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Parafluorofentanyl - DrugsPRO substance guide

Parafluorofentanyl: Parafluorofentanyl is an extremely potent synthetic opioid and analogue of fentanyl, originally developed by Janssen Pharmaceutica during the 1960s. It is classified as a depressant with significant habit-forming potential. The substance remains rare, and relatively little is kno

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