Sibutramine was withdrawn from most markets in 2010 due to increased risk of cardiovascular events (heart attack and stroke), particularly in patients with pre-existing cardiovascular disease. It is a centrally acting appetite suppressant that acts as a prodrug, metabolized to more potent active metabolites (M1 and M2) with longer half-lives. Unlike amphetamines, it does not cause monoamine release and does not produce euphoria. Contraindicated in patients with history of cardiovascular disease, uncontrolled hypertension, eating disorders, severe depression, mania, or narrow-angle glaucoma. Regular blood pressure monitoring is essential during use.
Sibutramine molecular structure diagram from the DrugsPRO substance library.
Also known as: Meridia, Siredia, Reductil, Sibutrex, Butramin, Medaria, (±)-Dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine
Classification
Chemical: Medicine
Psychoactive: Stimulant
Tag: Appetite-suppressant
Tag: Pharmaceutical
Tag: Withdrawn-medication
Effects
Stimulation
Increased Energy
Increased Heart Rate
Increased Blood Pressure
Dry Mouth
Insomnia
Anxiety
Dizziness
Talkativeness
Alertness Enhancement
Wakefulness
Focus Enhancement
Appetite Suppression
Light Sensitivity
Dehydration
Photophobia
Spontaneous Physical Sensations
Increased Libido
Routes of Administration
Oral
Dosage
Threshold: 5 mg
Light: 5-10 mg
Common: 10-15 mg
Strong: 15-20 mg
Heavy: 20+ mg
Duration
Onset: 0.5-2 h
Comeup: 1-2 h
Peak: 3-6 h
Offset: 12-24 h
After Effects: 18-36 h
Total Duration: 18-30 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Sibutramine - DrugsPRO substance guide
Sibutramine: Sibutramine was withdrawn from most markets in 2010 due to increased risk of cardiovascular events (heart attack and stroke), particularly in patients with pre-existing cardiovascular disease. It is a centrally acting appetite suppressant that acts as a prodrug, metabolized to more pote
