Oral bioavailability doubles when taken with food; dosing on an empty stomach delivers only ~36% of the intended exposure, leading users to redose unnecessarily. Therapeutic QTc prolongation averages 10-20 msec, but heavy recreational doses (>160 mg/day) or IV diversion markedly increases torsade risk. IM ziprasidone reaches Cmax within 60 minutes and has a 2-5 hour half-life, making it a common ER 'trip-stopper'. Forum reports describe 60-120 mg oral as a reliable 'stimulant-comedown knockout', with sleep onset 2-4 hours after dosing. Extrapyramidal reactions (akathisia, dystonia) and very rare tardive dystonia have occurred after weeks on 80-120 mg/day regimens.
Ziprasidone molecular structure diagram from the DrugsPRO substance library.
Also known as: Geodon, Zeldox, Zipwell
Classification
Chemical: Medicine
Psychoactive: Depressant
Tag: Antipsychotic
Tag: Benzisothiazolyl piperazine
Tag: Pharmaceutical
Tag: Second-generation antipsychotic
Tag: Sedative
Effects
Sedation
Somnolence
Akathisia
Restlessness
Akathisia Like Movement
Motor Impairment
Emotion Suppression
Motivation Suppression
Anxiety Suppression
Motor Control Loss
Cognitive Fatigue
Dizziness
Dulled Perception
Acuity Suppression
Appetite Suppression
Orgasm Suppression
Open Eye Visuals
Dehydration
Routes of Administration
Oral
Dosage
Threshold: 10 mg
Light: 10 mg - 40 mg
Common: 40 mg - 80 mg
Strong: 80 mg - 120 mg
Heavy: 120+ mg
Duration
Onset: 1-3 h
Comeup: 1-2 h
Peak: 3-6 h
Offset: 6-10 h
After Effects: 10-24 h
Total Duration: 6-12 h
Intramuscular
Dosage
Threshold: 5 mg
Light: 5 mg - 10 mg
Common: 10 mg - 20 mg
Strong: 20 mg - 40 mg
Heavy: 40+ mg
Duration
Onset: 0.25-0.5 h
Comeup: 0.5-1 h
Peak: 0.5-1.5 h
Offset: 2-4 h
After Effects: 6-24 h
Total Duration: 4-10 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Ziprasidone - DrugsPRO substance guide
Ziprasidone: Oral bioavailability doubles when taken with food; dosing on an empty stomach delivers only ~36% of the intended exposure, leading users to redose unnecessarily. Therapeutic QTc prolongation averages 10-20 msec, but heavy recreational doses (>160 mg/day) or IV diversion markedly increas
