Library
25CN-NBOH
25CN-NBOH is one of the most 5-HT2A-selective agonists discovered; cyano substitution markedly reduces off-target 5-HT2B and 5-HT2C activity compared to other NBOMe/NBOH compounds. Buccal or sublingual absorption is strongly preferred over oral. Users consistently report pronounced vasoconstriction and mouth numbness. Visuals are intense and geometric, with cognitive effects more acute than LSD at equivalent intensity. Exercise extreme caution with dosing due to high potency and vasoconstriction effects.
Also known as: Nboh-2c-cn, 2C-CN-NBOH
Classification
- Chemical: Phenethylamine
- Psychoactive: Psychedelic
- Tag: Hallucinogen
- Tag: Research-Chemical
Effects
- Vasoconstriction
- Tachycardia
- Temperature Regulation Suppression
- Stimulation
- Physical Discomfort
- Numbness
- Time Distortion
- Euphoria
- Emotion Suppression
- Cognitive Disorganization
- Thought Deceleration
- Anxiety
- Geometric Visual Patterning
- Complex Visual Imagery
- Tactile Suppression
- Tracers
- Open Eye Visuals
- Geometric Imagery
Routes of Administration
Buccal
Dosage
- Threshold: 50 – 100 µg
- Light: 100 – 300 µg
- Common: 300 – 800 µg
- Strong: 800 – 1200 µg
- Heavy: 1200 + µg
Duration
- Onset: 0.25-0.75 h
- Comeup: 0.5-1 h
- Peak: 1-3 h
- Offset: 3-5 h
- After Effects: 5-12 h
- Total Duration: 4-11 h
Sublingual
Dosage
- Threshold: 50 – 100 µg
- Light: 100 – 300 µg
- Common: 300 – 800 µg
- Strong: 800 – 1200 µg
- Heavy: 1200 + µg
Duration
- Onset: 0.25-0.75 h
- Comeup: 0.5-1 h
- Peak: 1-3 h
- Offset: 3-5 h
- After Effects: 5-12 h
- Total Duration: 4-11 h
Intranasal
Dosage
- Threshold: 20-50 ug
- Light: 50-150 ug
- Common: 150-400 ug
- Strong: 400-700 ug
- Heavy: 700 ug
Duration
- Onset: 0.03-0.08 h
- Comeup: 0.25-0.5 h
- Peak: 1-3 h
- Offset: 3-5 h
- After Effects: 12 h
Insufflated
Dosage
- Heavy: 700 + µg
- Light: 50 – 150 µg
- Common: 150 – 400 µg
- Strong: 400 – 700 µg
- Threshold: 20 – 50 µg
Duration
- Onset: 0-0.17 h
- Peak: 0.5-2 h
- Offset: 2-4 h
- After Effects: 4-10 h
- Total Duration: 3-8 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
Links
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