4C-D (Ariadne) is a rare psychedelic phenethylamine first synthesized by Alexander Shulgin in 1968. It was developed by Bristol Laboratories and reached phase 3 clinical trials as an antidepressant and motivational enhancer before being discontinued for economic reasons. Unlike typical psychedelics, 4C-D produces minimal hallucinogenic effects even at high doses, instead causing mental alertness, mood enhancement, and mild stimulation. Shulgin described it as producing 'the alert of a psychedelic, with none of the rest of the package.' Clinical trials suggested efficacy for depression, Parkinson's disease symptoms, and cognitive enhancement in elderly patients. Very limited human data exists beyond Shulgin's testing and unpublished clinical trials.
Also known as: 4c-dom, Ariadne, Bl-3912, Α-et-2c-d, Dimoxamine, Α-ethyl-2C-D
Classification
Chemical: Amphetamine
Chemical: Phenethylamine
Psychoactive: Entactogen
Psychoactive: Psychedelic
Psychoactive: Stimulant
Tag: Research-Chemical
Effects
Stimulation
Teeth Grinding
Jaw Tension
Physical Discomfort
Increased Heart Rate
Insomnia
Motivation Enhancement
Wakefulness
Thought Acceleration
Analysis Enhancement
Cognitive Euphoria
Emotion Enhancement
Color Enhancement
Pattern Recognition Enhancement
Acuity Enhancement
Increased Music Appreciation
Open Eye Visuals
Tactile Enhancement
Routes of Administration
Oral
Dosage
Threshold: 5–10 mg (PiHKAL-era very mild alerts reported near 20 mg)
Light: 10–25 mg
Common: 25–60 mg (anecdotal: 40–100 mg)
Strong: 60–100 mg
Heavy: 100+ mg (anecdotal outliers reported up to ~150 mg; higher doses increase unknown risk)
Duration
Onset: 0.33-1.5 h
Comeup: 0.5-1 h
Peak: 1-3 h
Offset: 2-4 h
After Effects: 0-6 h
Total Duration: 4-8 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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4C-D - Guía de sustancias de DrugsPRO
4C-D: 4C-D (Ariadne) is a rare psychedelic phenethylamine first synthesized by Alexander Shulgin in 1968. It was developed by Bristol Laboratories and reached phase 3 clinical trials as an antidepressant and motivational enhancer before being discontinued for economic reasons. Unlike typical psyched
