4-HO-MET is a synthetic psychedelic tryptamine first synthesized by Alexander Shulgin and documented in his 1997 book TiHKAL. Structurally related to psilocin, it produces effects through serotonin receptor agonism. Users typically describe it as more recreational than psilocybin mushrooms, characterized by vivid colorful visuals with a less mentally intense headspace. Reports of human use emerged in the late 2000s following its appearance on the research chemical market. Very little data exists regarding its toxicity profile.
Also known as: Homet, Cz-74, Colour, Metocina, Etocina, Metilcibina
Classification
Chemical: Tryptamine
Psychoactive: Psychedelic
Tag: Common
Tag: Research-Chemical
Tag: substituted tryptamine
Effects
Spontaneous Tactile Sensations
Sedation
Nausea
Pupil Dilation
Increased Heart Rate
Spontaneous Bodily Sensations
Thought Connectivity
Thought Acceleration
Novelty Enhancement
Immersion Enhancement
Time Distortion
Analysis Enhancement
Synaesthesia
Hallucinations
Drifting
Tracers
After Images
Symmetrical Texture Repetition
Routes of Administration
Oral
Dosage
Heavy: 45+ mg
Light: 5-15 mg
Common: 10 – 15 mg
Strong: 25-45 mg
Threshold: 2 – 8 mg
Duration
Onset: 0.25-0.67 h
Comeup: 0.5-1 h
Peak: 2-3 h
Offset: 1-1.5 h
After Effects: 2-12 h
Total Duration: 4-6 h
Insufflated
Dosage
Heavy: 20 mg+
Light: 5 – 10 mg
Common: 8 – 15 mg
Strong: 12 – 20 mg
Threshold: 2 – 7 mg
Duration
Onset: 0.08-0.42 h
Comeup: 0.33-1 h
Peak: 1-2 h
Offset: 0.5-1 h
After Effects: 0-12 h
Total Duration: 2-4 h
Smoked
Dosage
Heavy: 60 mg
Light: 10 – 25 mg
Common: 25 – 35 mg
Strong: 35 – 60 mg
Threshold: 5 mg
Duration
Onset: 0-0.03 h
Intravenous
Dosage
Light: 5 mg
Common: 10 – 15 mg
Strong: 20 mg
Threshold: 5 mg
Duration
Onset: 0.03-0.17 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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4-HO-MET - Guía de sustancias de DrugsPRO
4-HO-MET: 4-HO-MET is a synthetic psychedelic tryptamine first synthesized by Alexander Shulgin and documented in his 1997 book TiHKAL. Structurally related to psilocin, it produces effects through serotonin receptor agonism. Users typically describe it as more recreational than psilocybin mushrooms
