DMXE is a designer dissociative of the arylcyclohexylamine class, structurally related to methoxetamine (MXE) in which the 3-methoxy group is replaced by a methyl substituent. It emerged on the recreational drug market around October 2020 and was first formally identified by a forensic laboratory in Denmark in February 2021. As a relatively novel research chemical, limited data exists regarding its safety profile, pharmacology, and long-term health effects.
DMXE molecular structure diagram from the DrugsPRO substance library.
Also known as: 3d-mxe, Warm-k, 3-me-2'-oxo-pce, Deoxymethoxetamine, 3-Methyleticyclidone
Classification
Chemical: Arylcyclohexylamine
Psychoactive: Dissociative
Tag: Hallucinogen
Effects
Sedation
Pain Relief
Nausea
Spontaneous Bodily Sensations
Incoordination
Stimulation
Dissociation
Anxiety Suppression
Euphoria
Introspection
Immersion Enhancement
Motor Control Loss
Increased Music Appreciation
Optical Sliding
Tactile Suppression
Visual Acuity Suppression
Double Vision
Frame Rate Suppression
Routes of Administration
Insufflated
Dosage
Heavy: 100+ mg
Light: 25 mg
Common: 20 – 35 mg
Strong: 35 – 60 mg
Threshold: 15–25 mg
Duration
Onset: 0.08-0.25 h
Comeup: 0.5-1.5 h
Peak: 0.5-1.5 h
Offset: 1.5-4 h
After Effects: 4-24 h
Total Duration: 4-6 h
Sublingual
Dosage
Heavy: 80 mg
Light: 15 – 30 mg
Common: 30 – 50 mg
Strong: 50 – 80 mg
Threshold: 10 mg
Duration
Onset: 0.25-0.5 h
Peak: 1-3 h
Oral
Dosage
Heavy: 150+ mg
Light: 50–70 mg
Common: 70–110 mg
Strong: 110–150 mg
Threshold: 30–50 mg
Duration
Onset: 0.33-0.67 h
Peak: 1-2 h
Offset: 2-5 h
After Effects: 5-7 h
Total Duration: 5-7 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
This static page is intended as a readable non-JS and prerender-friendly library export.
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DMXE - Guía de sustancias de DrugsPRO
DMXE: DMXE is a designer dissociative of the arylcyclohexylamine class, structurally related to methoxetamine (MXE) in which the 3-methoxy group is replaced by a methyl substituent. It emerged on the recreational drug market around October 2020 and was first formally identified by a forensic laborat
