3,4,5-Trimethoxyphenethylamine (also known as mescaline) is a naturally-occurring classical psychedelic substance of the phenethylamine class. It occurs naturally in the peyote cactus (Lophophora williamsii), San Pedro cactus (Echinopsis pachanoi), Peruvian Torch cactus (Echinopsis peruviana) as well as the Cactaceae plant and the Fabaceae bean families. It is one of the oldest known hallucinogens and the parent compound of the psychedelic phenethylamines, one of the two major subclasses of psychedelic compounds (along with tryptamines).
Mescalina molecular structure diagram from the DrugsPRO substance library.
Also known as: San, Mesc, Peyote, Cactus, Buttons, Peyote alkaloid, San Pedro/Trichocereus cactus alkaloid, Mescaline HCl
Classification
Chemical: Phenethylamine
Psychoactive: Psychedelic
Tag: Common
Tag: Hallucinogen
Tag: Plant-based
Tag: Scaline
Tag: Substituted phenethylamine
Effects
Spontaneous Tactile Sensations
Stimulation
Nausea
Salivation
Increased Heart Rate
Pupil Dilation
Thought Acceleration
Novelty Enhancement
Time Distortion
Analysis Enhancement
Multiple Thought Streams
Personal Bias Suppression
Tactile Enhancement
Bodily Control Enhancement
Hallucinations
Synaesthesia
Drifting
Tracers
Routes of Administration
Oral
Dosage
Heavy: 500-700 mg
Light: 100 – 200 mg
Common: 200 – 300 mg
Strong: 300 – 500 mg
Threshold: 100 mg
Duration
Onset: 1-3 h
Comeup: 1-2 h
Peak: 4-6 h
Offset: 6-14 h
After Effects: 12-20 h
Total Duration: 10-20 h
Dried
Dosage
Common: 20-30 g
Heavy: 40 g
Light: 10-20 g
Strong: 30-40 g
Duration
No data available for this section yet.
Fresh
Dosage
Common: 100-150 g
Heavy: 200 g
Light: 50-100 g
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Mescaline - Guía de sustancias de DrugsPRO
Mescaline: 3,4,5-Trimethoxyphenethylamine (also known as mescaline) is a naturally-occurring classical psychedelic substance of the phenethylamine class. It occurs naturally in the peyote cactus (Lophophora williamsii), San Pedro cactus (Echinopsis pachanoi), Peruvian Torch cactus (Echinopsis peruvi
