Tranilcipromina

Tranylcypromine is a non-selective, irreversible MAOI typically reserved for treatment-resistant major depressive disorder. Requires strict dietary restrictions to avoid tyramine-rich foods, which can cause life-threatening hypertensive crisis. Allow adequate washout periods when switching from other antidepressants (typically 2 weeks, but 5 weeks for fluoxetine). Effects persist for days to weeks after discontinuation due to irreversible MAO inhibition. Higher doses may produce stimulant-like effects due to structural similarity to amphetamine.

Also known as: Tcp, 2-pcpa, Parnate, Skf-385

Classification

Chemical: Amphetamine
Chemical: Medicine
Chemical: Phenethylamine
Psychoactive: Stimulant
Tag: Antidepressant
Tag: MAOI
Tag: Pharmaceutical
Tag: Phenylcyclopropylamine

Effects

Stimulation
Increased Energy
Insomnia
Restlessness
Orthostatic Hypotension
Sedation
Mood Lift
Anxiety
Agitation
Dizziness
Euphoria
Motivation Enhancement
Light Sensitivity
Dulled Perception
Appetite Suppression
Sexual Dysfunction
Disinhibition
Tactile Suppression

Routes of Administration

Oral

Dosage

Threshold: 5-10 mg
Light: 10–20 mg/day
Common: 30–40 mg/day (divided)
Strong: 50–60 mg/day (divided)
Heavy: >60 mg/day (not recommended; exceeds typical max of 60 mg/day)

Duration

Onset: 1-2 h
Comeup: 1-2 h
Peak: 2-4 h
Offset: 240-504 h
After Effects: 240-504 h
Total Duration: 240-504 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

dose.wiki

Links

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