CBG is the biosynthetic precursor of THC and CBD but produces no appreciable intoxication or euphoria. It acts as a weak partial agonist at CB1/CB2 receptors with low affinity, but is a potent α2-adrenergic agonist and 5-HT1A antagonist, which may underlie its alert-yet-calm profile. Human clinical trial data (20 mg oral) demonstrated significant anxiety reduction without cognitive impairment. Safety concerns exist due to α2-adrenergic activation potentially causing sedation, dry mouth, and reduced blood pressure/heart rate. Metabolized primarily by CYP2J2, CYP2C9, CYP2C19, and CYP3A4 enzymes.
CBG molecular structure diagram from the DrugsPRO substance library.
Also known as: Cannabigerol, CBG isolate
Classification
Chemical: Cannabinoid
Chemical: Medicine
Psychoactive: Nootropic
Tag: Supplement
Effects
Physical Euphoria
Pain Relief
Inflammation Suppression
Sedation
Dry Mouth
Dry Eyes
Anxiety Suppression
Mood Enhancement
Cognitive Enhancement
Motivation Enhancement
Euphoria
Increased Focus
Appetite Enhancement
Brightness Enhancement
Routes of Administration
Oral
Dosage
Threshold: 5 mg
Light: 5 – 15 mg
Common: 15 – 40 mg
Strong: 40 – 80 mg
Heavy: 80 mg +
Duration
Onset: 0.5-1.5 h
Peak: 1-2 h
Offset: 2-4 h
After Effects: 0-4 h
Total Duration: 4-6 h
Sublingual
Dosage
Threshold: 3 mg
Light: 3 – 10 mg
Common: 10 – 30 mg
Strong: 30 – 60 mg
Heavy: 60 mg +
Duration
Onset: 0.17-0.5 h
Peak: 1-2 h
Offset: 1-3 h
After Effects: 4 h
Vaporized
Dosage
Threshold: 1 mg
Light: 1 – 5 mg
Common: 5 – 15 mg
Strong: 15 – 30 mg
Heavy: 30 mg +
Duration
Onset: 0.02-0.08 h
Peak: 0.25-0.5 h
Offset: 0.5-1.5 h
After Effects: 0-2 h
Total Duration: 1-3 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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CBG - DrugsPRO ainejuhend
CBG: CBG is the biosynthetic precursor of THC and CBD but produces no appreciable intoxication or euphoria. It acts as a weak partial agonist at CB1/CB2 receptors with low affinity, but is a potent α2-adrenergic agonist and 5-HT1A antagonist, which may underlie its alert-yet-calm profile. Human clin
