Cocaine is a tropane alkaloid stimulant derived from the leaves of coca plants native to South America. It has a long history of medical use as a topical anesthetic owing to its intrinsic vasoconstrictor properties and voltage-gated sodium channel inhibition, though its high abuse potential has largely supplanted this role. Cocaine functions as a serotonin–norepinephrine–dopamine reuptake inhibitor, producing euphoria and heightened alertness. It is notably cardiotoxic and carries a significant potential for compulsive redosing and addiction.
Kokaiin molecular structure diagram from the DrugsPRO substance library.
Also known as: Coke, Blow, Snow, Yayo, Girl, Flake, Yeyo, Perico, White, Charlie, Crack, Rock, Base
Classification
Chemical: Tropane
Psychoactive: Stimulant
Tag: Alkaloid
Tag: Common
Tag: Habit-Forming
Effects
Increased Heart Rate
Stimulation
Abnormal Heartbeat
Sublingual Numbing
Pain Relief
Vasoconstriction
Thought Acceleration
Focus Enhancement
Ego Inflation
Wakefulness
Motivation Enhancement
Euphoria
Disinhibition
Dehydration
Appetite Suppression
Increased Libido
Tactile Enhancement
Auditory Enhancement
Routes of Administration
Insufflated
Dosage
Heavy: 150 mg
Light: 20 – 50 mg
Common: 50 – 100 mg
Strong: 100 – 150 mg
Threshold: 5-10 mg
Bioavailability: 150 mg
Duration
Onset: 0.05-0.17 h
Comeup: 0.08-0.2 h
Peak: 0.25-0.67 h
Offset: 0.17-0.42 h
After Effects: 1-4 h
Total Duration: 0.75-1.5 h
Oral
Dosage
Heavy: 225+ mg
Light: 13 – 75 mg
Common: 75 – 150 mg
Strong: 150 – 225 mg
Threshold: 10-20 mg
Bioavailability: 225 mg
Duration
Onset: 0.5-0.67 h
Comeup: 0.67-0.83 h
Peak: 1-3 h
Offset: 0.17-0.42 h
After Effects: 1-3 h
Smoked
Dosage
Heavy: 100+ mg
Light: 5 – 15 mg
Common: 15 – 30 mg
Strong: 30 – 45 mg
Threshold: 5-10 mg
Bioavailability: 100 mg
Duration
Onset: 0.02-0.05 h
Comeup: 0.02-0.03 h
Peak: 0.03-0.17 h
Offset: 0.02-0.08 h
After Effects: 20-120 h
Total Duration: 5-15 h
Intravenous
Dosage
Bioavailability: 100%
Heavy: 100+ mg
Light: 10-30 mg
Common: 30-60 mg
Strong: 60-100 mg
Threshold: 5-10 mg
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Cocaine - DrugsPRO ainejuhend
Cocaine: Cocaine is a tropane alkaloid stimulant derived from the leaves of coca plants native to South America. It has a long history of medical use as a topical anesthetic owing to its intrinsic vasoconstrictor properties and voltage-gated sodium channel inhibition, though its high abuse potential
