Dihydrocodeine is a semi-synthetic opioid analgesic of the morphinan class. Developed in Germany in 1908 and first marketed in 1911, it was originally created during efforts to find more effective antitussive medications to curb the spread of airborne diseases like tuberculosis. Slightly more potent than codeine, it is prescribed for moderate to severe pain, dyspnea, and cough suppression. It is commonly sold in combination formulations containing paracetamol or aspirin, which pose additional overdose risks if not accounted for.
Asetyylidihydrokodeiini molecular structure diagram from the DrugsPRO substance library.
Also known as: Dhc, Df-118, Drocode, Parzone, Paramol, 6-acetyldihydrocodeine, ADC, 6-ADC, Dihydrocodeine bitartrate
Classification
Chemical: Medicine
Chemical: Morphinan
Chemical: Opioid
Psychoactive: Depressant
Tag: Habit-Forming
Tag: Research-Chemical
Tag: Sedative
Effects
Physical Euphoria
Sedation
Pain Relief
Cough Suppression
Itchiness
Respiratory Depression
Cognitive Euphoria
Anxiety Suppression
Thought Deceleration
Compulsive Redosing
Euphoria
Mood Lift
Dulled Perception
Decreased Libido
Increased Music Appreciation
Cognitive Dysphoria
Internal Hallucination
Closed Eye Visuals
Routes of Administration
Oral
Dosage
Threshold: 50 mg
Light: 50 – 100 mg
Common: 100 – 150 mg
Strong: 150 – 200 mg
Heavy: 150-200 mg
Duration
Onset: 0.5-0.75 h
Comeup: 0.5-1 h
Peak: 1-2 h
Offset: 2-3 h
After Effects: 6-12 h
Total Duration: 4-7 h
Rectal
Dosage
Threshold: 5 mg
Light: 15 – 40 mg
Common: 40 – 70 mg
Strong: 70 – 130 mg
Heavy: 130 + mg
Duration
Onset: 0.25-0.75 h
Comeup: 0.5-1 h
Peak: 0.75-1.5 h
Offset: 2-3 h
After Effects: 1-3 h
Total Duration: 4-7 h
Insufflated
Dosage
Threshold: 5 mg
Light: 10 – 20 mg
Common: 20 – 40 mg
Strong: 40 – 80 mg
Heavy: 80 + mg
Duration
Onset: 0.08-0.25 h
Comeup: 0.25-0.5 h
Peak: 0.75-1.5 h
Offset: 2.5-4 h
After Effects: 1-3 h
Total Duration: 3.5-6 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
This static page is intended as a readable non-JS and prerender-friendly library export.
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Acetyldihydrocodeine - DrugsPRO aineopas
Acetyldihydrocodeine: Dihydrocodeine is a semi-synthetic opioid analgesic of the morphinan class. Developed in Germany in 1908 and first marketed in 1911, it was originally created during efforts to find more effective antitussive medications to curb the spread of airborne diseases like tuberculosis
