Library
AM-1248
AM-1248 is an extremely potent full agonist at CB1 and CB2 receptors with binding affinities approximately 1000-fold higher than THC. Effects are qualitatively similar to very strong cannabis concentrates but arrive faster and without the self-titration possible when smoking plant material. Users report a steep dose-response curve where accidentally doubling a planned dose can turn a mild experience into overwhelming dysphoria, panic, or unconsciousness. Powder is usually applied to herbal carrier; uneven distribution creates dangerous "hot spots." Emergency presentations have included severe agitation, seizures, and acute kidney injury. No specific antagonists exist; supportive care is recommended.
Classification
- Chemical: Cannabinoid
- Chemical: Synthetic cannabinoid
- Tag: Aminoalkylindole
- Tag: Hallucinogen
- Tag: Research-Chemical
Effects
- Bodily Warmth
- Tachycardia
- Xerostomia
- Nausea
- Sedation
- Dry Mouth
- Euphoria
- Anxiety
- Anxiety Suppression
- Time Distortion
- Memory Suppression
- Panic
- Visual Snow
- Tactile Enhancement
- Open Eye Visuals
- Closed Eye Visuals
- Closedeye Imagery
- Dulled Perception
Routes of Administration
Vaporized
Dosage
- Threshold: <0.3 mg
- Light: 0.3-1 mg
- Common: 1-3 mg
- Strong: 3-5 mg
- Heavy: >5 mg
Duration
- Onset: 0.01-0.03 h
- Peak: 0.08-0.5 h
- Offset: 0.5-1 h
- After Effects: 2-6 h
- Total Duration: 1-2 h
Oral
Dosage
- Threshold: ~1 mg
- Light: 1-3 mg
- Common: 3-6 mg
- Strong: 6-10 mg
- Heavy: >10 mg
Duration
- Onset: 0.5-1.5 h
- Peak: 1-3 h
- Offset: 1-2 h
- After Effects: 2-12 h
- Total Duration: 3-6 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
Links
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