CBL is a photodegradation product of cannabichromene (CBC), occurring naturally in aged or UV-exposed Cannabis. Human pharmacology remains almost completely unstudied; however, recent 2025 research revealed CBL has high affinity for the 5-HT1A serotonin receptor, acting as a potent positive allosteric modulator at low concentrations. A 1976 study in rabbits showed convulsions and death at 8 mg/kg, though this limited two-animal study offers minimal guidance for human safety. Commercial CBL products are not currently available. People subject to workplace or legal drug testing should note that CBL may be reported generically as a cannabinoid, though it is not scheduled under UN drug conventions.
CBL molecular structure diagram from the DrugsPRO substance library.
Also known as: Cbp, Cannabipinol, Pentylcannabicyclol, Cannabicyclol
Classification
Chemical: Cannabinoid
Chemical: Synthetic cannabinoid
Tag: Not psychoactive
Tag: Research-Chemical
Effects
No data available for this section yet.
Routes of Administration
Oral
Dosage
Heavy: No data mg
Light: No data mg
Common: No data mg
Strong: No data mg
Duration
No data available for this section yet.
Sublingual
Dosage
Heavy: No data mg
Light: No data mg
Common: No data mg
Strong: No data mg
Duration
No data available for this section yet.
Inhaled
Dosage
Heavy: No data mg
Light: No data mg
Common: No data mg
Strong: No data mg
Duration
No data available for this section yet.
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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CBL - DrugsPRO aineopas
CBL: CBL is a photodegradation product of cannabichromene (CBC), occurring naturally in aged or UV-exposed Cannabis. Human pharmacology remains almost completely unstudied; however, recent 2025 research revealed CBL has high affinity for the 5-HT1A serotonin receptor, acting as a potent positive all
