MDPV is a synthetic stimulant of the cathinone and pyrrolidine classes, first developed in the 1960s by Boehringer Ingelheim as a potential amphetamine alternative. It acts primarily as a norepinephrine-dopamine reuptake inhibitor and is considered one of the most potent stimulants available. MDPV gained notoriety after 2004 when it appeared in products marketed as 'bath salts' sold in convenience stores. It is known for producing strong euphoria with mild empathogenic qualities, though it carries significant risk of compulsive redosing.
MDPV molecular structure diagram from the DrugsPRO substance library.
Also known as: Magic, Nrg-1, Bath salts, Super coke, Crack, Rock, Base, Hard, Roxanne, Rocks, Ivory Wave, Cloud Nine, Vanilla Sky
Classification
Chemical: Cathinone
Psychoactive: Entactogen
Psychoactive: Stimulant
Tag: Habit-Forming
Tag: MDxx
Tag: Pyrrolidine
Tag: Pyrrolidinophenone
Tag: Research-Chemical
Tag: Synthetic cathinone
Tag: substituted pyrrolidine
Effects
Creativity Enhancement
Increased Heart Rate
Increased Blood Pressure
Nystagmus
Stimulation
Bruxism
Compulsive Redosing
Euphoria
Empathy Enhancement
Anxiety
Paranoia
Motivation Enhancement
Cognitive Dysphoria
Increased Libido
Appetite Suppression
Auditory Hallucination
Hallucinations
Sexual Dysfunction
Routes of Administration
Oral
Dosage
Heavy: 25 mg+
Light: 4–10 mg
Common: 5 – 11 mg
Strong: 10 – 20 mg
Threshold: 2-6 mg
Duration
Onset: 0.25-0.5 h
Comeup: 0.5-1 h
Peak: 0.5-3 h
Offset: 0.5-2 h
After Effects: 2-48 h
Total Duration: 2-7 h
Insufflated
Dosage
Heavy: 20 mg+
Light: 2 – 5 mg
Common: 5 – 11 mg
Strong: 10 – 20 mg
Threshold: 1-3 mg
Duration
Onset: 0.083-0.333 h
Comeup: 0.25-0.5 h
Peak: 0.5-2 h
Offset: 0.5-1 h
After Effects: 2-48 h
Total Duration: 2-3.5 h
Rectal
Dosage
Common: 6-12 mg
Light: 3-8 mg
Strong: 10-25 mg
Threshold: 1-5 mg
Heavy: 25 mg+
Duration
Onset: 0.083-0.167 h
Peak: 0.5-2 h
Offset: 2-5 h
After Effects: 2-48 h
Total Duration: 2-5 h
Smoked
Dosage
Heavy: 200+ mg (free‑base)
Light: 20–40 mg (free‑base)
Common: 40–100 mg (free‑base)
Strong: 100–200 mg (free‑base)
Threshold: 10–20 mg (free‑base)
Duration
Onset: 0.08-0.17 h
Peak: 0.5-2 h
Offset: 5-15 h
After Effects: 15-60 h
Total Duration: 5-20 h
Vaporized
Dosage
Heavy: 8 mg+
Light: 1–2 mg
Common: 2–4 mg
Strong: 4–8 mg
Threshold: ~1 mg
Duration
Onset: 0.008-0.05 h
Peak: 0.1-0.5 h
Offset: 1-3 h
After Effects: 2-48 h
Total Duration: 1-3 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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MDPV - DrugsPRO aineopas
MDPV: MDPV is a synthetic stimulant of the cathinone and pyrrolidine classes, first developed in the 1960s by Boehringer Ingelheim as a potential amphetamine alternative. It acts primarily as a norepinephrine-dopamine reuptake inhibitor and is considered one of the most potent stimulants available.
