25T-NBOMe is a potent N-2-methoxybenzyl derivative of 2C-T with sub-milligram activity due to high 5-HT2A receptor affinity. It is considerably less studied than 25I-NBOMe and 25C-NBOMe, with minimal human pharmacokinetic data available. Oral bioavailability is poor; sublingual or buccal administration is required. Physiological risks parallel other NBOMes: vasoconstriction, tachycardia, hypertension, hyperthermia, nausea, and anxiety. Severe toxicity including seizures, rhabdomyolysis, and cardiac events have been reported with related NBOMe compounds, particularly at high doses or when combined with stimulants.
Also known as: 2c-t-nbome, Nbome-2c-t, 25T2-NBOMe, 25T4-NBOMe, 25T7-NBOMe
Classification
Chemical: Phenethylamine
Psychoactive: Psychedelic
Psychoactive: Stimulant
Tag: Hallucinogen
Tag: Research-Chemical
Effects
Cognitive Stimulation
Vasoconstriction
Nausea
Stimulation
Physical Discomfort
Increased Heart Rate
Euphoria
Empathy Enhancement
Time Distortion
Spiritual Or Introspective Thinking
Anxiety
Paranoia
Synaesthesia
Visual Patterning
Color Enhancement
Visual Drifting
Closedeye Visuals
Open Eye Visuals
Routes of Administration
Sublingual
Dosage
Threshold: 200-300 ug
Light: 300-600 ug
Common: 600-1200 ug
Strong: 1200–2000 µg
Heavy: 2000+ µg
Duration
Onset: 0.25-0.75 h
Comeup: 0.5-1 h
Peak: 2-4 h
Offset: 2-3 h
After Effects: 6-12 h
Total Duration: 4-11 h
Buccal
Dosage
Threshold: 250-400 ug
Light: 400-700 ug
Common: 700-1400 ug
Strong: 1400–2200 µg
Heavy: 2200+ µg
Duration
Onset: 0.25-0.75 h
Comeup: 0.5-1 h
Peak: 2-4 h
Offset: 2-3 h
After Effects: 2-6 h
Insufflated
Dosage
Threshold: 100-200 ug
Light: 200-400 ug
Common: 400-700 ug
Strong: 700-1000 ug
Heavy: 1000+ µg
Duration
Onset: 0.08-0.25 h
Comeup: 0.33-0.67 h
Peak: 2-4 h
Offset: 2-3 h
After Effects: 4-12 h
Total Duration: 3-8 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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25T-NBOMe - Guide des substances DrugsPRO
25T-NBOMe: 25T-NBOMe is a potent N-2-methoxybenzyl derivative of 2C-T with sub-milligram activity due to high 5-HT2A receptor affinity. It is considerably less studied than 25I-NBOMe and 25C-NBOMe, with minimal human pharmacokinetic data available. Oral bioavailability is poor; sublingual or buccal
