Library
3-CAF
3-CAF is a positional isomer of the neurotoxic para-chloramphetamine (PCA). In vitro work (Urban et al., 2012) indicates potent serotonin and moderate dopamine/noradrenaline release (EC50 ≈ 35 nM for 5-HT, 280 nM for DA). Neurotoxicity appears reduced compared with PCA but long-term serotonergic depletion has been observed in rat cortex at ≥10 mg/kg (Kindred et al., 2015). Human use reports are extremely scarce; users describe a ‘clean’, MDMA-lite empathy with typical amphetamine stimulation and minimal visuals. Marked hyperthermia and bruxism were noted at >30 mg.
Also known as: 3-chloroamphetamine, 3-CA, M-CA, Meta-chloroamphetamine
Classification
- Chemical: Amphetamine
- Psychoactive: Entactogen
- Psychoactive: Psychedelic
- Psychoactive: Stimulant
- Tag: Research-Chemical
Effects
- Increased Energy And Talkativeness
- Mild Entactogenic Body High
- Pupil Dilation
- Bruxism Jaw Tension
- Mild Hyperthermia Sweating
- Insomnia At Higher Doses
- Euphoria
- Heightened Empathysociability
- Talkativeness
- Empathy Enhancement
- Sociability Enhancement
- Anxiety
- Appetite Suppression
- Light Sensitivity
- Color Enhancement
- Open Eye Visuals
- Tactile Enhancement
Routes of Administration
Oral
Dosage
- Threshold: 5 mg
- Light: 5-10 mg
- Common: 10-20 mg
- Strong: 20-35 mg
- Heavy: 35 mg + (not advised)
Duration
- Onset: 0.33-0.75 h
- Peak: 1.5-3 h
- Offset: 1-2 h
- After Effects: 0.02-0.07 h
- Total Duration: 4-7 h
Insufflated
Dosage
- Threshold: 2 mg
- Light: 2-5 mg
- Common: 5-12 mg
- Strong: 12-20 mg
- Heavy: 20 mg + (not advised)
Duration
- Onset: 0.33-0.75 h
- Peak: 0.75-2 h
- Offset: 2-3.5 h
- After Effects: 0.02-0.07 h
- Total Duration: 3-5 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
Links
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