4-Methylephedrine (4-ME) is a phase-I reduction metabolite of the popular cathinone mephedrone (4-MMC). In users who take raw or poorly washed 4-MMC, small amounts may already be present as an impurity. Pure 4-ME occasionally appears on the grey market but formal pharmacology is limited. Available in-vitro data show it acts as a norepinephrine > dopamine transporter inhibitor/releaser with little serotonergic action, explaining its 'clean' peripheral stimulation and modest euphoria. CRITICAL WARNING: Reports suggest 4-ME may be significantly more cardiotoxic than ephedrine, with pronounced cardiovascular stress (tachycardia, vasoconstriction, blood-pressure rise) being more pronounced than central euphoria.
Also known as: 4-me, 4-mmc metabolite, Dihydromephedrone, P-methylephedrine
Classification
Chemical: Amphetamine
Chemical: Cathinone
Psychoactive: Stimulant
Tag: Cathinone-metabolite
Tag: Research-Chemical
Effects
Peripheral Stimulation
Increased Energy
Sweating
Jaw Tension Bruxism
Insomnia
Urinary Retention
Mild Euphoria
Increased Sociability
Talkativeness
Alertness Enhancement
Tactile Enhancement
Appetite Suppression
Light Sensitivity
Routes of Administration
Oral
Dosage
Threshold: 15 mg
Light: 20-40 mg
Common: 40-80 mg
Strong: 80-120 mg
Heavy: 120 mg
Duration
Onset: 0.33-0.67 h
Peak: 1-2 h
Offset: 1-3 h
After Effects: 1-4 h
Insufflated
Dosage
Threshold: 5-10 mg
Light: 10-25 mg
Common: 25-50 mg
Strong: 50-80 mg
Heavy: 80 mg
Duration
Onset: 0.08-0.17 h
Peak: 1-2 h
Offset: 1-3 h
After Effects: 1-4 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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4-Methylephedrine - Guide des substances DrugsPRO
4-Methylephedrine: 4-Methylephedrine (4-ME) is a phase-I reduction metabolite of the popular cathinone mephedrone (4-MMC). In users who take raw or poorly washed 4-MMC, small amounts may already be present as an impurity. Pure 4-ME occasionally appears on the grey market but formal pharmacology is l
