6-MAM is the primary active metabolite of heroin and is responsible for heroin's characteristic rapid rush and intense euphoria. It crosses the blood-brain barrier more efficiently than morphine and appears in brain tissue at higher concentrations than heroin itself. Rarely sold in pure form; most encounters arise from black-tar heroin or deliberate synthesis. Approximately 30% more potent than heroin by weight. Extreme respiratory depression risk when combined with other CNS depressants.
Also known as: 6-am, 6-acetylmorphine, 6-monoacetylmorphine, 6-ACM, 6-ACO, 6-Acetylmorphin, 6-Monoacetylmorphin, Monoacetylmorphin
Classification
Chemical: Medicine
Chemical: Morphinan
Chemical: Opioid
Psychoactive: Depressant
Tag: Habit-Forming
Tag: Precursor
Tag: Research-Chemical
Effects
Physical Euphoria
Pain Relief
Sedation
Respiratory Depression
Muscle Relaxation
Nausea
Cognitive Euphoria
Anxiety Suppression
Thought Deceleration
Compulsive Redosing
Euphoria
Contentment
Routes of Administration
Intravenous
Dosage
Threshold: 2 mg
Light: 3-5 mg
Common: 5-10 mg
Strong: 10-15 mg
Heavy: 15 mg+
Duration
Comeup: 0.02-0.03 h
Peak: 0.08-0.5 h
Offset: 60-120 h
After Effects: 120-180 h
Onset: 0-0.5 h
Total Duration: 90-180 h
Insufflated
Dosage
Threshold: 5 mg
Light: 5-15 mg
Common: 15-25 mg
Strong: 25-35 mg
Heavy: 35 mg+
Duration
Onset: 0.02-0.08 h
Comeup: 0.08-0.17 h
Peak: 0.17-0.75 h
Offset: 60-120 h
After Effects: 120-240 h
Total Duration: 120-240 h
Smoked
Dosage
Threshold: 2 mg
Light: 2-5 mg
Common: 5-15 mg
Strong: 15-25 mg
Heavy: 25 mg+
Duration
Comeup: 0.02-0.05 h
Peak: 0.08-0.5 h
Offset: 60-120 h
After Effects: 120-240 h
Onset: 0.25-1 h
Total Duration: 120-240 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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6-MAM - Guide des substances DrugsPRO
6-MAM: 6-MAM is the primary active metabolite of heroin and is responsible for heroin's characteristic rapid rush and intense euphoria. It crosses the blood-brain barrier more efficiently than morphine and appears in brain tissue at higher concentrations than heroin itself. Rarely sold in pure form;
