Cyputylone is structurally similar to methylone with cyclohexyl substitution at the amine nitrogen. Early user reports highlight marked body-load including bruxism, hypertension, nausea, and diarrhea even at lower doses around 25 mg rectal. Insufflated material produces strong nasal numbness and vasoconstriction but relatively minimal euphoria compared to methylone or eutylone. The substance has a brief peak with significant residual stimulation promoting compulsive redosing. Suspected mild MAO-B inhibition warrants avoiding tyramine-rich foods for 24 hours post-dose until further data emerge.
Cyputylone molecular structure diagram from the DrugsPRO substance library.
Also known as: N-cyclohexylmethylone, N-CMC, Common misspelling: Cuiputylone
Classification
Chemical: Cathinone
Psychoactive: Entactogen
Psychoactive: Stimulant
Tag: Research-Chemical
Effects
Stimulation
Teeth Grinding
Jaw Clenching
Increased Heart Rate
Increased Blood Pressure
Difficulty Urinating
Cognitive Euphoria
Compulsive Redosing
Anxiety
Wakefulness
Euphoria
Empathy Enhancement
Increased Music Appreciation
Spontaneous Physical Sensations
Tactile Enhancement
Dehydration
Light Sensitivity
Appetite Suppression
Routes of Administration
Oral
Dosage
Threshold: 20 mg
Light: 20-60 mg
Common: 60-120 mg
Strong: 120-200 mg
Heavy: 200+ mg
Duration
Onset: 0.33-0.67 h
Comeup: 0.5-1 h
Peak: 0.5-1.5 h
Offset: 1.5-4 h
After Effects: 4-12 h
Total Duration: 3-6 h
Insufflated
Dosage
Threshold: 10 mg
Light: 10-30 mg
Common: 30-75 mg
Strong: 75-120 mg
Heavy: 120+ mg
Duration
Onset: 0.08-0.17 h
Comeup: 0.25-0.5 h
Peak: 0.25-0.75 h
Offset: 0.75-2.5 h
After Effects: 2-10 h
Total Duration: 2-4 h
Rectal
Dosage
Threshold: 15 mg
Light: 15-30 mg
Common: 30-60 mg
Strong: 60-90 mg
Heavy: 90+ mg
Duration
Onset: 0.08-0.17 h
Comeup: 0.25-0.5 h
Peak: 0.5-1.5 h
Offset: 2-4 h
After Effects: 4-8 h
Harm Reduction
Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.
Sources
Substance data is aggregated from the following public harm-reduction and reference sources.
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Cyputylone - Guide des substances DrugsPRO
Cyputylone: Cyputylone is structurally similar to methylone with cyclohexyl substitution at the amine nitrogen. Early user reports highlight marked body-load including bruxism, hypertension, nausea, and diarrhea even at lower doses around 25 mg rectal. Insufflated material produces strong nasal numb
