Diphénhydramine

Diphenhydramine is a first-generation antihistamine of the ethanolamine class, first developed in 1943 by George Rieveschl and widely available over the counter under the brand name Benadryl. Primarily used to treat allergies and insomnia, it possesses anticholinergic properties functionally similar to tropane alkaloids found in nightshade plants. At high doses, it acts as a potent deliriant, producing intensely realistic hallucinations alongside significant physical discomfort and dysphoria.

Also known as: Dph, Nytol, Sominex, Zzzquil, Benylin, Diphenhydramin

Classification

Chemical: Medicine
Psychoactive: Psychedelic
Tag: Antihistamine
Tag: Common
Tag: Ethanolamine
Tag: Hallucinogen

Effects

Spontaneous Tactile Sensations
Sedation
Physical Fatigue
Muscle Cramps
Muscle Spasms
Nausea
Depression
Anxiety
Thought Deceleration
Emotion Suppression
Information Processing Suppression
Amnesia
Cognitive Dysphoria
Perception Of Increased Weight
Dehydration
Tactile Hallucinations
Photophobia
Auditory Suppression

Routes of Administration

Oral

Dosage

Heavy: 700 mg
Light: 100 - 200 mg
Common: 150 – 300 mg
Strong: 300 – 500 mg
Threshold: 25 mg
Bioavailability: 700 mg

Duration

Onset: 0.5-1.5 h
Comeup: 0.75-1.5 h
Peak: 1-4 h
Offset: 2-6 h
After Effects: 2-24 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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