Hydroxyzine

Hydroxyzine is a first-generation antihistamine of the diphenylmethane and piperazine classes, first developed in 1956. Primarily prescribed for allergic conditions such as itchiness and urticaria, it also exhibits anxiolytic and sedative properties, making it useful for treating generalized anxiety disorder and insomnia. Hydroxyzine is additionally employed to reduce nausea and has been used to potentiate opioid analgesia while diminishing opioid-related side effects like itchiness.

Also known as: Atarax, Hyzine, Rezine, Vistaril, Vistaject

Classification

Chemical: Medicine
Chemical: Piperazine
Psychoactive: Deliriant
Psychoactive: Depressant
Tag: Antihistamine
Tag: Anxiolytic
Tag: Dephenylmethane
Tag: Sedative

Effects

Decreased Blood Pressure
Sedation
Sleepiness
Headache
Nausea
Incoordination
Anxiety Suppression
Confusion
Cognitive Fatigue
Motor Control Loss
Reduced Anxiety
Drowsiness
Dehydration
Auditory Hallucination
Hallucinations
Dulled Perception
Blurred Vision
Cognitive Dysphoria

Routes of Administration

Oral

Dosage

Common: 25 – 100 mg

Duration

Onset: 0.33-1 h
After Effects: 1-8 h

Harm Reduction

Check interactions before mixing substances, pay attention to dose spacing and hydration, and treat all dosage guidance as approximate rather than guaranteed safe.

Sources

Substance data is aggregated from the following public harm-reduction and reference sources.

Links

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